127159-66-4

Basic information

• Product Name: sodium 2-fluorobenzenesulfinate
• Synonyms: sodium 2-fluorobenzenesulfinate
• CAS NO: 127159-66-4
• Molecular Weight: 182.151
• Mol File: 127159-66-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: sodium 2-fluorobenzenesulfinate(CAS DataBase Reference)
• NIST Chemistry Reference: sodium 2-fluorobenzenesulfinate(127159-66-4)
• EPA Substance Registry System: sodium 2-fluorobenzenesulfinate(127159-66-4)

Safety Data

• Hazardous Substances Data: 127159-66-4(Hazardous Substances Data)

Upstream product

• 2905-21-7 2-fluorobenzenesulfonyl chloride 
• 348-54-9 2-Fluoroaniline 
• 7446-09-5 sulfur dioxide 
• 12775-96-1 copper 

Downstream Products

• 30058-40-3 2-fluorobenzenesulfonamide 
• 613657-01-5 4-[(2-fluorophenyl)sulfonyl]morpholine 
• 1632154-30-3 5-(2-fluorophenyl)-6-phenylthiazolo[3,2-b][1,2,4]triazole 

Relevant articles and documents

Visible-light-promotedE-selective synthesis of α-fluoro-β-arylalkenyl sulfidesviathe deoxygenation/isomerization process

Regioselective synthesis of α-fluoro-β-arylalkenyl sulfides has been established withgem-difluoroalkenes and sodium sulfinates in a transition-metal-free manner. A series of control experiments were executed to demonstrate thiol radicals and anions as the proposed intermediates. Notably, regioselectiveZ→Eisomerization was achieved under green light irradiation in the absence of a photoinitiator.

Enhancing the Potential of Miniature-Scale DNA-Compatible Radical Reactions via an Electron Donor-Acceptor Complex and a Reversible Adsorption to Solid Support Strategy

DNA-encoded library (DEL) technology is a powerful tool in the discovery of bioactive probe molecules and drug leads. Mostly, the success in DEL technology stems from the molecular diversity of the chemical libraries. However, the construction of DELs has been restricted by the idiosyncratic needs and the required low concentration (～1 mM or less) of the library intermediate. Here, we report visible-light-promoted on-DNA radical coupling reactions via an electron donor-acceptor (EDA) complex and a reversible adsorption to solid support (RASS) strategy. This protocol provides a unique solution to the challenges of increasing the reactivity of highly diluted DNA substrates and reducing the residues of heavy metals from photocatalysts. A series of on-DNA indole sulfone and selenide derivatives were obtained with good to quantitative conversions. It is anticipated that these mild-condition on-DNA radical reactions will significantly improve the chemical diversity of DELs and find widespread utility to DEL construction.

Diastereoselective Monofluorocyclopropanation Using Fluoromethylsulfonium Salts

Diarylfluoromethylsulfonium salts, alternatives to freons or advanced fluorinated building blocks, are bench stable and easy-to-use sources of direct fluoromethylene (:CHF) transfer to alkenes. These salts enabled development of a trans-selective monofluorinated Johnson-Corey-Chaykovsky reaction with vinyl sulfones or vinyl sulfonamides to access synthetically challenging monofluorocyclopropane scaffolds. The described method offers rapid access to monofluorinated cyclopropane building blocks with further functionalization opportunities to deliver more complex synthetic targets diastereoselectively.