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127180-75-0

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127180-75-0 Usage

Type of compound

Alcohol

Substituents

Chloro, phenyl, and propan-1-ol groups

Uses

Synthesis of pharmaceuticals and agrochemicals, chiral building block in asymmetric synthesis

Safety precautions

Toxic chloro group, can cause skin, eye, and respiratory irritation; should be used in well-ventilated areas with appropriate personal protective equipment.

Check Digit Verification of cas no

The CAS Registry Mumber 127180-75-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,1,8 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 127180-75:
(8*1)+(7*2)+(6*7)+(5*1)+(4*8)+(3*0)+(2*7)+(1*5)=120
120 % 10 = 0
So 127180-75-0 is a valid CAS Registry Number.

127180-75-0Relevant articles and documents

Mechanistically Guided Design of an Efficient and Enantioselective Aminocatalytic α-Chlorination of Aldehydes

Hutchinson, George,Alamillo-Ferrer, Carla,Burés, Jordi

supporting information, p. 6805 - 6809 (2021/05/29)

The enantioselective aminocatalytic α-chlorination of aldehydes is a challenging reaction because of its tendency to proceed through neutral intermediates in unselective pathways. Herein we report the rational shift to a highly selective reaction pathway involving charged intermediates using hexafluoroisopropanol as solvent. This change in mechanism has enabled us to match and improve upon the yields and enantioselectivities displayed by previous methods while using cheaper aminocatalysts and chlorinating agents, 80-95% less amount of catalyst, convenient temperatures, and shorter reaction times.

A general, enantioselective synthesis of 2-substituted thiomorpholines and thiomorpholine 1,1-dioxides

Reed, Carson W.,Lindsley, Craig W.

supporting information, (2019/09/10)

In the course of our drug discovery programs, we had need to access chiral, 2-substituted thiomorpholines and their oxidized congeners, thiomorpholine 1,1-dioxides. Here, we disclose a high-yielding, general protocol for the enantioselective synthesis of

Trichloromethanesulfonyl chloride: A chlorinating reagent for aldehydes

Jimeno, Ciril,Cao, Lidong,Renaud, Philippe

, p. 1251 - 1255 (2016/02/19)

Trichloromethanesulfonyl chloride (CCl3SO2Cl), a commercially available reagent, has been found to perform efficiently in the α-chlorination of aldehydes, including its catalytic asymmetric version, under very mild reaction conditions. Under our reaction conditions, this compound outperforms typical chlorinating reagents for organic synthesis, facilitates workup and purification of the product, and minimizes the formation of toxic, chlorinated organic waste.

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