1271948-76-5Relevant articles and documents
Structure-Based Design of Selective β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2
Fujimoto, Kazuki,Matsuoka, Eriko,Asada, Naoya,Tadano, Genta,Yamamoto, Takahiko,Nakahara, Kenji,Fuchino, Kouki,Ito, Hisanori,Kanegawa, Naoki,Moechars, Diederik,Gijsen, Harrie J. M.,Kusakabe, Ken-Ichi
, p. 5080 - 5095 (2019/05/28)
BACE1 inhibitors hold potential as agents in disease-modifying treatment for Alzheimer's disease. BACE2 cleaves the melanocyte protein PMEL in pigment cells of the skin and eye, generating melanin pigments. This role of BACE2 implies that nonselective and
2 -AMINODIHYDRO [1, 3] THIAZINES AS BACE 2 INHIBITORS FOR THE TREATMENT OF DIABETES
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, (2011/04/18)
This invention relates to the use of aminodihydrothiazines of the formula wherein R1 to R3 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof, and pharmaceutical compositions con