127221-02-7

Basic information

• Product Name: 5-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 5-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER;Ethyl 5-(ethoxycarbonyl)indole-2-carboxylate;DIETHYL 2,5-INDOLE DICARBOXYLATE;5-Ethoxycarbonylindole-2-carboxylic;Diethyl 1H-indole-2,5-dicarboxylate
• CAS NO: 127221-02-7
• Molecular Formula: C14H15NO4
• Molecular Weight: 261.27
• Product Categories: Indole/indoline/oxindole;Indole;Indoles
• Mol File: 127221-02-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 420.183 °C at 760 mmHg
• Flash Point: 207.92 °C
• Appearance: /
• Density: 1.24 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER(127221-02-7)
• EPA Substance Registry System: 5-ETHOXYCARBONYLINDOLE-2-CARBOXYLIC ACID ETHYL ESTER(127221-02-7)

Safety Data

• Hazardous Substances Data: 127221-02-7(Hazardous Substances Data)

Usage

General Description

5-Ethoxycarbonylindole-2-carboxylic acid ethyl ester is a chemical compound that falls under the category of indole-based substances. It is recognized by its distinct structural components comprising an indole core, an ethoxycarbonyl and ethyl ester group. The double-ring structure of its indole core provides it with stability as well as versatility for chemical modifications and interactions. While there isn't a wealth of specific information available in terms of its exact uses and properties, it can be inferred from its structure that it may have potential applications in the fields of organic synthesis, material science, and pharmacology. However, its exact safety, toxicity and biological impact are still subject to further studies.

Upstream product

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Relevant articles and documents

Synthesis method for preparing 2-substituted indole derivative

The invention relates to a synthesis method for preparing a 2-substituted indole derivative. The method includes the following steps: mixing aromatic amine compounds (I), ketone compounds (II) and a drying agent in an organic solvent; adding a palladium catalyst; and reacting in an aerobic weak acid environment to prepare the indole compounds (III). (I), (II) and (III) are as shown in the specification, wherein R1 is selected from hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkanoyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, hydroxyl, substituted or unsubstituted amino, substituted or unsubstituted phenyl, pyridyl and heterocyclic aryl; (I) can be pyridylamine, pyrimidylamine, pyridazinam or pyrazinamide which may further be substituted or unsubstituted; and the substituents are selected fromone or more C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkanoyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, hydroxyl, amino; and R2 is selected from C1-C6 alkyl, formate groups or C1-C6 alkylamide groups.

Novel aromatic compounds and poly(oxyalkylene) containing aromatic compounds possessing antibacterial, antifungal or antitumor activity

The present invention provides novel compounds possessing one or more of the following activities: antibacterial, antifungal and antitumor activity. The compounds are of Formula (I): Pharmaceutical compositions containing these compounds, methods of making and methods for using these compounds are also provided.

Regiospecific functionalization of indole-2-carboxylates and diastereoselective preparation of the corresponding indolines

The N-acyl derivatives of 3-substituted indole-2-carboxylates prepared through several routes were submitted to catalytic hydrogenation affording either cis- or trans-indoline diastereomers after quantitative C-2 epimerization.