1273029-19-8Relevant articles and documents
Discovery of a 2′-fluoro-2′-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties
Kirschberg, Thorsten A.,Metobo, Sammy,Clarke, Michael O.,Aktoudianakis, Vangelis,Babusis, Darius,Barauskas, Ona,Birkus, Gabriel,Butler, Thomas,Byun, Daniel,Chin, Gregory,Doerffler, Edward,Edwards, Thomas E.,Fenaux, Martijn,Lee, Rick,Lew, Willard,Mish, Michael R.,Murakami, Eisuke,Park, Yeojin,Squires, Neil H.,Tirunagari, Neeraj,Wang, Ting,Whitcomb, Mark,Xu, Jie,Yang, Huiling,Ye, Hong,Zhang, Lijun,Appleby, Todd C.,Feng, Joy Y.,Ray, Adrian S.,Cho, Aesop,Kim, Choung U.
, p. 1840 - 1847 (2017/04/04)
A series of 2′-fluorinated C-nucleosides were prepared and tested for anti-HCV activity. Among them, the triphosphate of 2′-fluoro-2′-C-methyl adenosine C-nucleoside (15) was a potent and selective inhibitor of the NS5B polymerase and maintained activity
