1273324-88-1

Basic information

• Product Name: bisebromoamide methyl ether
• Synonyms: bisebromoamide methyl ether
• CAS NO: 1273324-88-1
• Molecular Weight: 1037.17
• Mol File: 1273324-88-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: bisebromoamide methyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: bisebromoamide methyl ether(1273324-88-1)
• EPA Substance Registry System: bisebromoamide methyl ether(1273324-88-1)

Safety Data

• Hazardous Substances Data: 1273324-88-1(Hazardous Substances Data)

Upstream product

• 1191115-30-6 bisebromoamide 
• 74-88-4 methyl iodide 

Relevant articles and documents

Revised structure and structure-activity relationship of bisebromoamide and structure of norbisebromoamide from the marine cyanobacterium Lyngbya sp.

Novel potent cytotoxic peptides bisebromoamide (1) and norbisebromoamide (2) have been isolated from the marine cyanobacterium Lyngbya sp. The planar structure of these peptides was elucidated through the extensive application of 1D and 2D NMR techniques. The absolute stereostructure of 1 was determined by chemical degradation followed by chiral HPLC analysis. Recently, Tao and co-workers achieved synthesis of bisebromoamide, and the configuration of thiazoline moiety was revised. We re-investigated the stereochemistry of thiazoline moiety of 1. The structure-activity relationships of bisebromoamide (1) were investigated with the use of natural and synthetic analogs. Furthermore, bisebromoamide (1) potently inhibited protein kinase: the phosphorylation of ERK in NRK cells by PDGF-stimulation was selectively inhibited by treatment with 10-0.1 μM of 1.