127343-08-2Relevant articles and documents
3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors. 7. Modification of the Hexahydronaphthalene Moiety of Simvastanin: 5-Oxygenated and 5-Oxa Derivatives
Duggan, Mark E.,Alberts, Alfred W.,Bostedor, Rick,Chao, Yu-sheng,Germershausen, John I.,et al.
, p. 2489 - 2495 (2007/10/02)
Modification of the hexahydronaphthalene ring 5-position in simvastatin 2a via oxygenation and oxa replacement afforded two series of derivatives which were evaluated in vitro for inhibition of 3-hydroxy-3-methylglutaryl-coenzyme.A reductase and acutely i
INTERMEDIATES AND PROCESSES IN THE PREPARATION OF 5-OXYGENATED HMG-COA REDUCTASE INHIBITORS
-
, (2008/06/13)
This invention relates to novel intermediates and novel processes for their preparation where said intermediates are useful in the preparation of 5'-oxygenated derivatives (I) of lovastation and analogs thereof at the 8'-acyl side chain and 6'-position of