127357-85-1Relevant articles and documents
Methods of modifying N-termini of a peptide or protein using transferases
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Page/Page column 19, (2016/08/03)
The invention includes a selective method of modifying the N-terminus of a protein using an aminoacyl tRNA transferase. In certain embodiments, the method comprises contacting a solution of the protein or peptide with a transferase and a derivative of a molecule, whereby the N-terminus of the protein or peptide is derivatized with the molecule.
Enzymes as synthetic catalysts: Mechanistic and active-site considerations of natural and modified chymotrypsin
West, J. Blair,Hennen, William J.,Lalonde, James L.,Bibbs, Jeffrey A.,Zhong, Ziyang,Meyer Jr., Edgar F.,Wong, Chi-Huey
, p. 5313 - 5320 (2007/10/02)
This paper describes the mechanistic investigation of α-chymotrypsin and [Met192-sulfoxide]-α-chymotrypsin-catalyzed peptide synthesis in a kinetically controlled process (i.e., aminolysis) and the relative stabilities of both enzymes in differ