1273578-50-9Relevant articles and documents
One-pot, two-step synthesis of 7-methylene-1,5-piperazine-fused 1,2,3-triazoles
Kuang, Lu,Ming, Peng,Wan, Chang-Feng,Chen, Jun-Min,Sheng, Shou-Ri
, p. 563 - 569 (2020/11/19)
A facile, one-pot two-step synthesis of 7-methylene-1,5-piperazine-fused 1,2,3-triazole derivatives has been developed. The protocol employs an N-allylation of N-propargylated amines with 2,3-dibromopropene in the presence of K2CO3 in DMSO and a CuI-catalyzed [3 + 2] cycloaddition reaction of the synthetic N-(2-bromoallyl)-N-propargyl amines with sodium azide sequentially. Such a method provides methylene-substituted 1,2,3-triazole fused piperazines with some advantages such as simple operation, high efficiency and good product yield (80–91%) through readily available starting materials.
A synthetic in alkyne endalkyne propylamine derivatives containing different substituents method of (by machine translation)
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Paragraph 0027, (2016/11/07)
The invention belongs to the field of organic synthesis technology, in particular to a kind of synthetic in alkyne endalkyne propylamine derivatives containing different substituents method. This invention, through a carbon-carbon single bond of activation between alkyne propylamine the mutual conversion of different, the rare-earth catalyst system, terminal alkyne as compounds with propargyl substituted secondary amine as raw material, the preparation containing various substituents alkyne endalkyne propylamine derivatives. The method of the invention the raw material sources are widespread or easy to prepare, simple and convenient operation, selectively controllable, high yield. (by machine translation)
Platinum-catalyzed cyclization reaction of alkynes: Synthesis of azepino[3,4-b]indol-1-ones
Gruit, Marina,Pews-Davtyan, Anahit,Beller, Matthias
experimental part, p. 1148 - 1159 (2011/04/15)
Novel azepino[3,4-b]indol-1-ones were synthesized from alkyne-substituted indole-2-carboxamides by catalytic intramolecular cyclization in the presence of PtCl2. The scope and limitations of this straightforward protocol are reported.