127408-31-5

Basic information

• Product Name: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE
• Synonyms: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE;Y-26763
• CAS NO: 127408-31-5
• Molecular Formula: C14H16N2O4
• Molecular Weight: 276.28784
• Product Categories: Potassium channel
• Mol File: 127408-31-5.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 455.4°Cat760mmHg
• Flash Point: 229.2°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 4.4E-09mmHg at 25°C
• Refractive Index: 1.615
• Storage Temp.: Store at RT
• PKA: 8.69±0.60(Predicted)
• CAS DataBase Reference: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE(127408-31-5)
• EPA Substance Registry System: N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE(127408-31-5)

Safety Data

• Hazardous Substances Data: 127408-31-5(Hazardous Substances Data)

Usage

Description

N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE is a complex organic compound with a unique molecular structure characterized by its cyano and hydroxy functional groups. It belongs to the class of acetamides and is derived from a benzopyran skeleton. N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE exhibits potential applications in various fields due to its distinct chemical properties and reactivity.

Uses

Used in Pharmaceutical Industry:
N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE is used as a pharmaceutical compound for its potential therapeutic applications. The compound's unique structure and functional groups may allow it to interact with specific biological targets, making it a candidate for the development of new drugs.
Used in Chemical Research:
In the field of chemical research, N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE serves as a valuable compound for studying its reactivity, stability, and potential reactions with other molecules. This can lead to the discovery of new chemical reactions and the synthesis of novel compounds with various applications.
Used in Material Science:
The compound's unique structure and properties may also find applications in material science, where it could be used to develop new materials with specific properties, such as improved strength, durability, or chemical resistance.
Used in Drug Delivery Systems:
Similar to gallotannin, N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE could be employed in drug delivery systems to improve the bioavailability and therapeutic outcomes of various drugs. Its unique structure may allow for the development of novel drug carriers and delivery methods.

Biological Activity

K ATP channel opener and active metabolite of Y-27152 (N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide ). In vitro, causes relaxation of contracted rat aortic rings (IC 50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic b-cells. In vivo, produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration.

InChI:InChI=1/C14H16N2O4/c1-8(17)16(19)12-10-6-9(7-15)4-5-11(10)20-14(2,3)13(12)18/h4-6,12-13,18-19H,1-3H3/t12-,13+/m1/s1