127419-15-2

Basic information

• Product Name: Boc-Phe(4-NO₂)-Gly-NH₂
• Synonyms: Boc-Phe(4-NO₂)-Gly-NH₂
• CAS NO: 127419-15-2
• Molecular Weight: 366.374
• Mol File: 127419-15-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Boc-Phe(4-NO₂)-Gly-NH₂(CAS DataBase Reference)
• NIST Chemistry Reference: Boc-Phe(4-NO₂)-Gly-NH₂(127419-15-2)
• EPA Substance Registry System: Boc-Phe(4-NO₂)-Gly-NH₂(127419-15-2)

Safety Data

• Hazardous Substances Data: 127419-15-2(Hazardous Substances Data)

Upstream product

• 33305-77-0 Boc-Phe(p-NO₂)-OH 
• 1668-10-6 glycinamide hydrochloride 

Downstream Products

• 127687-52-9 prolyl-p-nitrophenylalanyl-glycinamide hydrochloride 
• 127331-70-8 Boc-Pro-Phe(4-NO₂)-Gly-NH₂ 

Relevant articles and documents

Synthesis and Biological Evaluation of Analogues of Pro-Leu-Gly-NH2 Modified at the Leucyl Residue

A series of analogues of Pro-Leu-Gly-NH2 (PLG) in which the leucine residue has been replaced with the aliphatic amino acids L-isoleucine, L-2-aminohexanoic acid (Ahx), L-2-aminopentanoic acid, and L-2-aminobutanoic acid and the aromatic amino acids L-phenylalanine, L-phenylglycine, L- and D-2-amino-4-phenylbutanoic acid, L-O-methyltyrosine, and L-4-nitrophenylalanine have been synthesized.These analogues were tested for their ability to enhance the binding of the dopamine receptor agonist 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADTN) to striatal dopamine receptors.Two of the abov e analogues, Pro-Ahx-Gly-NH2 (3) and Pro-Phe-Gly-NH2 (6), showed significant activity in this assay system.Pro-Ahx-Gly-NH2 produced a 16percent enhancement of ADTN binding at 0.1 μM, while Pro-Phe-Gly-NH2 enhanced the binding of ADTN by 31percent at a concentration of 1 μM.