127437-33-6

Basic information

• Product Name: (3-Fluoro-4-isobutoxy-phenyl)-acetic acid
• Synonyms: (3-Fluoro-4-isobutoxy-phenyl)-acetic acid
• CAS NO: 127437-33-6
• Molecular Weight: 226.248
• Mol File: 127437-33-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3-Fluoro-4-isobutoxy-phenyl)-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (3-Fluoro-4-isobutoxy-phenyl)-acetic acid(127437-33-6)
• EPA Substance Registry System: (3-Fluoro-4-isobutoxy-phenyl)-acetic acid(127437-33-6)

Safety Data

• Hazardous Substances Data: 127437-33-6(Hazardous Substances Data)

Upstream product

• 452-14-2 2-(4-fluoro-3-methoxyphenyl)acetic acid 
• 458-09-3 (3-fluoro-4-hydroxyphenyl)acetic acid 
• 404-90-0 2-(3-fluoro-4-methoxyphenyl)acetonitrile 
• 351-52-0 3-fluoro-4-methoxybenzyl chloride 
• 321-28-8 1-fluoro-2-methoxybenzene 
• 78-77-3 Isobutyl bromide 
• 79280-92-5 (3-fluoro-4-hydroxy-phenyl)-acetic acid methyl ester 

Relevant articles and documents

COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES

The present disclosure relates to compounds according to Formula (I), useful for treating diseases.

USE OF QSAR IN DESIGN OF ANTIINFLAMMATORY FLUORINATED ARYLALKANOIC ACIDS

A series of 3-fluoro-4-alkoxyphenylalkanoic acids III was synthetized and their antiinflammatory activity and fibrinolytic capacity was evaluated.The suitable fluorinated derivative with better pharmacological profile than 3-chloro-4-benzyloxyphenylacetic acid (benzofenac) was selected.Experimental, biological activities of acids III were compared with those calculated by introducing the physico-chemical parameters into the formerly derived regression equations.Good coincidence was found out, as well as similarity of the regression equations derived for the originalseries of acids extended by the acids III.Lipophilicity of the acids under study was evaluated by partition thin-layer chromatography; the values of log P of benzyloxy derivatives IIIc-IIIf were lower than tabulated values - probably due to the intramolecular hydrophobic interactions of aromatic nuclei.