127462-54-8

Basic information

• Product Name: (S)-2-((R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-2-{[(S)-2-((E)-(2S,6R,8S)-8-hydroxy-2,4,6-trimethyl-non-4-enoylamino)-propionyl]-methyl-amino}-propionylamino)-propionic acid
• CAS NO: 127462-54-8
• Molecular Weight: 773.825
• Mol File: 127462-54-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-2-((R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-2-{[(S)-2-((E)-(2S,6R,8S)-8-hydroxy-2,4,6-trimethyl-non-4-enoylamino)-propionyl]-methyl-amino}-propionylamino)-propionic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-2-{[(S)-2-((E)-(2S,6R,8S)-8-hydroxy-2,4,6-trimethyl-non-4-enoylamino)-propionyl]-methyl-amino}-propionylamino)-propionic acid(127462-54-8)
• EPA Substance Registry System: (S)-2-((R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-2-{[(S)-2-((E)-(2S,6R,8S)-8-hydroxy-2,4,6-trimethyl-non-4-enoylamino)-propionyl]-methyl-amino}-propionylamino)-propionic acid(127462-54-8)

Safety Data

• Hazardous Substances Data: 127462-54-8(Hazardous Substances Data)

Upstream product

• 127462-53-7 (S)-2-[(R)-3-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-2-({(S)-2-[(E)-(2S,6R,8S)-8-(tert-butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-non-4-enoylamino]-propionyl}-methyl-amino)-propionylamino]-propionic acid tert-butyl ester 
• 156706-65-9 (E)-(2S,6R,8S)-8-((S)-2-{(R)-2-[((S)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionylamino}-propionyloxy)-2,4,6-trimethyl-non-4-enoic acid 4-methoxy-benzyl ester 
• 117289-84-6 (E)-(2S,6R,8S)-8-{[tert-butyl(dimethyl)silyl]oxy}-2,4,6-trimethylnon-4-enoic acid 
• 117405-40-0 (3S,4R,6S)-6-tert-butyldimethylsiloxy-3-hydroxy-2,4-dimethyl-1-heptene 
• 117289-82-4 6-(tert-Butyl-dimethyl-silanyloxy)-2,4-dimethyl-hept-1-en-3-ol 
• 127462-46-8 2-<(1'R,3'S)-3'-hydroxy-1'-methyl>butyl-1,3-dithiane 
• 127462-51-5 (S)-2-{(R)-2-[((S)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionylamino}-propionic acid tert-butyl ester 
• 127462-50-4 (S)-2-{(R)-2-[((S)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid tert-butyl ester 
• 127462-49-1 (S)-2-[((R)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid benzyl ester 
• 127462-52-6 (S)-2-{(R)-2-[((S)-2-Amino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-3-iodo-phenyl]-propionylamino}-propionic acid tert-butyl ester 
• 127462-48-0 O-tert-butyldimethylsilyl-N-Boc-N-methyl-D-tyrosine benzyl ester 
• 129439-64-1 (S)-2-[((R)-2-tert-Butoxycarbonylamino-propionyl)-methyl-amino]-3-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionic acid 
• 127462-47-9 O-tert-butyldimethylsilyl-N-Boc-D-tyrosine benzyl ester 
• 129453-35-6 O-tert-butyldimethylsilyl-N-methyl-D-tyrosine benzyl ester 

Downstream Products

• 127462-55-9 (E)-(3S,6R,9S,12S,16R,18S)-6-[4-(tert-Butyl-dimethyl-silanyloxy)-3-iodo-benzyl]-3,7,9,12,14,16,18-heptamethyl-1-oxa-4,7,10-triaza-cyclooctadec-14-ene-2,5,8,11-tetraone 
• 108675-63-4 geodiamolide A 

Relevant articles and documents

An expeditious synthesis of geodiamolide a, an 18-membered cytotoxic depsipeptide from marine sponges

Geodiamolide A (1) has been efficiently synthesized from the polypropionate and tripeptide units using the Evans asymmetric alkylation, the Mitsunobu esterification, and the macrolactamization with diphenyl phosphorazidate (DPPA) as key steps. Efficient esterification between the complex polyketide and tripeptide units was also realized under high pressure conditions.