127517-27-5

Basic information

• Product Name: 2-tert-butoxyaniline
• CAS NO: 127517-27-5
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.2322
• Mol File: 127517-27-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 253°C at 760 mmHg
• Flash Point: 103.2°C
• Density: 0.999g/cm³
• Vapor Pressure: 0.0187mmHg at 25°C
• Refractive Index: 1.529
• CAS DataBase Reference: 2-tert-butoxyaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-tert-butoxyaniline(127517-27-5)
• EPA Substance Registry System: 2-tert-butoxyaniline(127517-27-5)

Safety Data

• Hazardous Substances Data: 127517-27-5(Hazardous Substances Data)

Upstream product

• 83747-12-0 2-(tert-butoxy)-1-nitrobenzene 
• 1493-27-2 ortho-nitrofluorobenzene 
• 6669-13-2 t-butyl phenyl ether 

Downstream Products

• 114559-80-7 1-(2-tert-Butoxy-phenyl)-3-((1R,3R,5S)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl)-urea 
• 1210825-82-3 (E)-2-tert-butoxy-N-(p-nitrophenylmethylene)phenylamine 
• 1246523-54-5 tert-butyl [2-(tert-butoxy)phenyl]carbamate 
• 864816-28-4 {7-hydroxy-5-methoxy-1,4-bis-(4-methoxyphenyl)-3-[2-(4-methoxyphenyl)ethyl]-3,6-dihydropyrrolo[2,3-c]carbazol-2-yl}-(4-methoxyphenyl)methanone 
• 864816-29-5 sulfuric acid 5-methoxy-2-(4-methoxybenzoyl)-1,4-bis-(4-methoxyphenyl)-3-[2-(4-methoxyphenyl)ethyl]-3,6-dihydropyrrolo[2,3-c]carbazol-7-yl ester 2,2,2-trichloroethyl ester 
• 900504-52-1 3-(4-methoxyphenethyl)-3,6-dihydro-5-methoxy-1,4-bis(4-methoxyphenyl)pyrrolo[2,3-c]carbazol-7-ol 
• 900504-65-6 5-methoxy-2-(4-methoxybenzyl)-3-(4-methoxyphenethyl)-1,4-bis(4-methoxyphenyl)-3,6-dihydropyrrolo[2,3-c]carbazol-7-ol 
• 900504-66-7 5-methoxy-2-(4-methoxybenzyl)-3-(4-methoxyphenethyl)-1,4-bis(4-methoxyphenyl)-3,6-dihydropyrrolo[2,3-c]carbazol-7-yl 2,2,2-trichloroethyl sulfate 
• 900504-67-8 5-hydroxy-2-(4-hydroxybenzyl)-3-(4-hydroxyphenethyl)-1,4-bis(4-hydroxyphenyl)-3,6-dihydropyrrolo[2,3-c]carbazol-7-yl 2,2,2-trichloroethyl sulfate 

Relevant articles and documents

Total Synthesis of Dictyodendrins A–F by the Gold-Catalyzed Cascade Cyclization of Conjugated Diyne with Pyrrole

The total synthesis of dictyodendrins A–F was achieved by using the gold(I)-catalyzed annulation of a conjugated diyne with N-Boc-pyrrole for direct construction of the pyrrolo[2,3-c]carbazole scaffold. Late-stage functionalization of the resulting pyrrolo[2,3-c]carbazole to introduce various substituents provided divergent access to dictyodendrins. Some dictyodendrin analogues exhibited inhibitory activities toward CDK2/CycA2 and GSK3.

Fe-Catalyzed Amination of (Hetero)Arenes with a Redox-Active Aminating Reagent under Mild Conditions

A novel and efficient Fe-catalyzed direct C?H amination (NH2) of arenes is reported using a new redox-active aminating reagent. The reaction is simple, and can be performed under air, mild, and redox-neutral conditions. This protocol has a broad substrate scope and could be used in the late-stage modification of bioactive compounds. Mechanistic studies demonstrate that a radical pathway could be involved in this transformation.

Total synthesis of dictyodendrins A-E

A highly efficient total synthesis of dictyodendrins A-E was accomplished. The synthesis features a novel benzyne-mediated one-pot indoline formation/cross-coupling sequence for the construction of a highly substituted key indoline intermediate. Peripheral substituents were introduced onto this intermediate in a modular fashion to complete the total synthesis of dictyodendrins A-E. A benzyne-mediated one-pot indoline formation/cross-coupling sequence is used for the construction of a highly substituted common indole intermediate. The peripheral substituents were introduced using a Friedel-Crafts reaction on the indole intermediate in a modular fashion to complete the total synthesis. Copyright