127560-52-5

Basic information

• Product Name: methyl 2-(2-methylphenyl)acrylate
• Synonyms: methyl 2-(2-methylphenyl)acrylate
• CAS NO: 127560-52-5
• Molecular Weight: 176.215
• Mol File: 127560-52-5.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: methyl 2-(2-methylphenyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(2-methylphenyl)acrylate(127560-52-5)
• EPA Substance Registry System: methyl 2-(2-methylphenyl)acrylate(127560-52-5)

Safety Data

• Hazardous Substances Data: 127560-52-5(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 766-47-2 1-ethynyl-2-methylbenzene 
• 40851-62-5 methyl o-tolylacetate 
• 644-36-0 o-methylphenylacetic acid 
• 34757-14-7 methyl 2-diazopropanoate 
• 95-46-5 2-methylphenyl bromide 
• 50-00-0 formaldehyd 
• 930-88-1 N-methylmaleimide 
• 33223-71-1 methyl 7-methylbicyclo[4.2.0]octa-1,3,5-triene-7-carboxylate 
• 16419-60-6 2-Methylphenylboronic acid 
• 33223-77-7 7-methyl-bicyclo[4.2.0]octa-1,3,5-triene-7-carboxylic acid 
• 163222-89-7 1,2-dihydrocyclobutabenzene-1-carboxylic acid 

Downstream Products

• 1203555-41-2 2-amino-5,6-dihydro-6-o-tolylpyrido[2,3-d]pyrimidin-7(8H)-one 
• 1203555-48-9 5,6-dihydro-2-(phenylamino)-6-o-tolylpyrido[2,3-d]pyrimidin-7(8H)-one 
• 1429641-15-5 C₁₀H₉ClO 
• 929030-18-2 (S)-1,3-dimethyl-3-o-tolylindolin-2-one 
• 109548-76-7 2-(methylene)phenylacetic acid 
• 1333260-18-6 methyl (E)-3-(2-bromo-4-methylphenyl)-2-o-tolylacrylate 
• 1333260-19-7 methyl (E)-3-(2-bromophenyl)-2-o-tolylacrylate 
• 1231755-92-2 methyl (2E)-2-(2-methylphenyl)-3-(4-methoxycarbonylphenyl)acrylate 
• 1187577-30-5 3-(2-methylphenyl)-3,4-dihydro-1H-quinolin-2-one 

Relevant articles and documents

Electrochemical oxidative: Z -selective C(sp2)-H chlorination of acrylamides

An electrochemical method for the oxidative Z-selective C(sp2)-H chlorination of acrylamides has been developed. This catalyst and organic oxidant free method is applicable across various substituted tertiary acrylamides, and provides access to a broad range of synthetically useful Z-β-chloroacrylamides in good yields (22 examples, 73% average yield). The orthogonal derivatization of the products was demonstrated through chemoselective transformations and the electrochemical process was performed on gram scale in flow.

Cobalt-Catalyzed Vinylic C-H Addition to Formaldehyde: Synthesis of Butenolides from Acrylic Acids and HCHO

A carboxyl-assisted C-H functionalization of acrylic acids with formaldehyde to give butenolides is described. It is the first time that the addition of an inert vinylic C-H bond to formaldehyde has been achieved via cobalt-catalyzed C-H activation. The unique reactivity of the cobalt species was observed when compared with related Rh or Ir catalysts. γ-Hydroxymethylated butenolides were produced by the treatment of Na2CO3 after the catalytic reaction in one pot.

Novel multi-dentate phosphines for Pd-catalyzed alkoxycarbonylation of alkynes promoted by H2O additive

A series of novel multi (bi-/tri-/tetra-)-dentate phosphines with good robustness against water and oxygen were synthesized and fully characterized. It was found that the developed ionic tri-dentate phosphine (L2′) enabled Pd-catalyzed alkoxycarbonylation of alkynes most efficiently while H2O was used as an additive instead of acid. As for L2′, its unique steric configuration with two types of potential P-P chelation modes (P?P distance of 4.31 ? and 4.36 ? respectively) to Pd-centre rendered the corresponding Pd-catalyst high activity and good stability for alkoxycarbonylation of alkynes. The in situ FT-IR analysis also verified that the formation and stability of Pd–H active species were greatly facilitated with the presence of L2′ as well as H2O additive. In addition, as an ionic phosphine, L2′ based PdCl2(MeCN)2 system immobilized in RTIL of [Bmim]NTf2 could be recycled for 7 runs without obvious activity loss or metal leaching.