1275608-89-3

Basic information

• Product Name: 4-(2-(4-nitrophenyl)hydrazinyl)-3-phenylfuran-2(5H)-one
• Synonyms: 4-(2-(4-nitrophenyl)hydrazinyl)-3-phenylfuran-2(5H)-one
• CAS NO: 1275608-89-3
• Molecular Weight: 311.297
• Mol File: 1275608-89-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2-(4-nitrophenyl)hydrazinyl)-3-phenylfuran-2(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-(4-nitrophenyl)hydrazinyl)-3-phenylfuran-2(5H)-one(1275608-89-3)
• EPA Substance Registry System: 4-(2-(4-nitrophenyl)hydrazinyl)-3-phenylfuran-2(5H)-one(1275608-89-3)

Safety Data

• Hazardous Substances Data: 1275608-89-3(Hazardous Substances Data)

Upstream product

• 91497-39-1 2-ethoxy-2-oxoethyl 2-phenylacetate 
• 23782-85-6 3-phenyltetronic acid 
• 1275608-70-2 C₁₀H₇ClO₂ 
• 100-16-3 4-nitrophenylhydrazone 
• 103-82-2 phenylacetic acid 

Relevant articles and documents

Synthesis, structure, molecular docking, and structure-activity relationship analysis of enamines: 3-Aryl-4-alkylaminofuran-2(5H)-ones as potential antibacterials

Thirty-one 3-aryl-4-alkylaminofuran-2(5H)-ones were designed, prepared and tested for their antibacterial activity. Some of them showed significant antibacterial activity against Gram-positive organisms, especially against Staphylococcus aureus ATCC 25923, but all were inactive against Gram-negative organisms. Out of these compounds, 3-(4-bromophenyl)-4-(2-(4-nitrophenyl) hydrazinyl)furan-2(5H)-one (4a11) showed the most potent antibacterial activity against S. aureus ATCC 25923 with MIC50 of 0.42 μg/mL. The enzyme assay revealed that the possible antibacterial mechanism of the synthetic compounds might be due to their inhibitory activity against tyrosyl-tRNA synthetase. Molecular dockings of 4a11 into S. aureus tyrosyl-tRNA synthetase active site were also performed. This inhibitor snugly fitting the active site might well explain its excellent inhibitory activity. Meanwhile, this modeling disclosed that a more suitable optimization strategy might be to modify the benzene ring at 3-position of furanone with hydrophilic groups.