1275991-44-0Relevant articles and documents
Lead optimization of a pyridine-carboxamide series as DGAT-1 inhibitors
Ting, Pauline C.,Lee, Joe F.,Zorn, Nicolas,Kim, Hyunjin M.,Aslanian, Robert G.,Lin, Mingxiang,Smith, Michelle,Walker, Scott S.,Cook, John,Van Heek, Margaret,Lachowicz, Jean
, p. 985 - 988 (2013/03/13)
The structure-activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described. The optimization of the initial lead compound 6 based on in vitro and in vivo activity led to the disc