1276013-77-4 Usage
Description
(R)-6-(3-Fluoro-benzyloxy)-N-(1,2,2-triMethyl-propyl)-nicotinaMide is a chiral organic compound with a unique molecular structure that features a 3-fluoro-benzyloxy group attached to the 6th position of the nicotinamide backbone. The presence of the tri-methyl propyl group at the nitrogen atom provides additional steric hindrance and lipophilicity, which may contribute to its biological activity and selectivity.
Uses
Used in Pharmaceutical Industry:
(R)-6-(3-Fluoro-benzyloxy)-N-(1,2,2-triMethyl-propyl)-nicotinaMide is used as a potent non-MPEP site mGlu5 positive allosteric modulator for its potential application in neuropathic treatment and anti-depressants. Its ability to modulate the activity of the mGlu5 receptor, a key target for the treatment of neurological disorders, makes it a promising candidate for the development of novel therapeutic agents.
In the context of neuropathic treatment, this compound may help alleviate pain and other symptoms associated with various neuropathies by modulating the activity of the mGlu5 receptor, which is involved in the transmission of pain signals in the central nervous system.
As an anti-depressant, (R)-6-(3-Fluoro-benzyloxy)-N-(1,2,2-triMethyl-propyl)-nicotinaMide may exert its effects by modulating the glutamatergic system, which plays a crucial role in the regulation of mood and emotional processing. By enhancing the activity of the mGlu5 receptor, this compound could potentially improve mood and alleviate depressive symptoms.
Overall, the unique structure and biological activity of (R)-6-(3-Fluoro-benzyloxy)-N-(1,2,2-triMethyl-propyl)-nicotinaMide make it a valuable compound for further research and development in the pharmaceutical industry, with potential applications in the treatment of neuropathic pain and depression.
Check Digit Verification of cas no
The CAS Registry Mumber 1276013-77-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,7,6,0,1 and 3 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1276013-77:
(9*1)+(8*2)+(7*7)+(6*6)+(5*0)+(4*1)+(3*3)+(2*7)+(1*7)=144
144 % 10 = 4
So 1276013-77-4 is a valid CAS Registry Number.
1276013-77-4Relevant articles and documents
O-BENZYL NICOTINAMIDE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS
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Page/Page column 117, (2011/04/19)
In one aspect, the invention relates to 0-benzyl nicotinamide analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making t
