1276030-38-6

Basic information

• Product Name: methyl 4-(2-oxo-2-(phenylamino)ethyl)benzoate
• Synonyms: methyl 4-(2-oxo-2-(phenylamino)ethyl)benzoate
• CAS NO: 1276030-38-6
• Molecular Weight: 269.3
• Mol File: 1276030-38-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 4-(2-oxo-2-(phenylamino)ethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(2-oxo-2-(phenylamino)ethyl)benzoate(1276030-38-6)
• EPA Substance Registry System: methyl 4-(2-oxo-2-(phenylamino)ethyl)benzoate(1276030-38-6)

Safety Data

• Hazardous Substances Data: 1276030-38-6(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 125587-45-3 methyl 4-[(2-tosylhydrazono)methyl]benzoate 
• 62-53-3 aniline 
• 52787-14-1 methyl 4-(2-methoxy-2-oxoethyl)benzoate 
• 18153-53-2 methyl 4-(N,N-dimethylaminomethyl)benzoate 

Relevant articles and documents

Manganese Catalyzed Direct Amidation of Esters with Amines

The transition metal catalyzed amide bond forming reaction of esters with amines has been developed as an advanced approach for overcoming the shortcomings of traditional methods. The broad scope of substrates in transition metal catalyzed amidations remains a challenge. Here, a manganese(I)-catalyzed method for the direct synthesis of amides from a various number of esters and amines is reported with unprecedented substrate scope using a low catalyst loading. A wide range of aromatic, aliphatic, and heterocyclic esters, even in fatty acid esters, reacted with a diverse range of primary aryl amines, primary alkyl amines, and secondary alkyl amines to form amides. It is noteworthy that this approach provides the first example of the transition metal catalyzed amide bond forming reaction from fatty acid esters and amines. The acid-base mechanism for the manganese(I)-catalyzed direct amidation of esters with amines was elucidated by DFT calculations.

Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters: Via C-N bond activation

An efficient palladium-catalyzed carbonylation reaction of readily available quaternary ammonium salts with CO is reported for the first time to afford arylacetamides and arylacetic acid esters via benzylic C-N bond cleavage. This protocol features mild reaction conditions under atmospheric pressure of CO, a redox-neutral process without an additional oxidant, and a broad substrate scope for various kinds of amines, alcohols and phenols.