1276041-95-2

Basic information

• Product Name: 2-benzyl-5-fluorobenzonitrile
• Synonyms: 2-benzyl-5-fluorobenzonitrile
• CAS NO: 1276041-95-2
• Molecular Weight: 211.239
• Mol File: 1276041-95-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-benzyl-5-fluorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl-5-fluorobenzonitrile(1276041-95-2)
• EPA Substance Registry System: 2-benzyl-5-fluorobenzonitrile(1276041-95-2)

Safety Data

• Hazardous Substances Data: 1276041-95-2(Hazardous Substances Data)

Upstream product

• 71-43-2 benzene 
• 217661-27-3 2-(bromomethyl)-5-fluorobenzonitrile 

Downstream Products

• 1276042-13-7 (2-benzoyl-5-fluorophenyl)(p-tolyl)methanone 

Relevant articles and documents

Copper-catalyzed benzylic C-H oxygenation under an oxygen atmosphere via N-H imines as an intramolecular directing group

Copper-catalyzed benzylic C-H oxygenation under an oxygen atmosphere was developed starting from carbonitriles and Grignard reagents via N-H imine intermediates. The present process is characterized by the following two-step sequence in a one-pot manner: (1) addition of Grignard reagents to carbonitriles to form N-H imines and (2) benzylic C-H oxygenation (C=O bond formation) triggered by 1,5-hydrogen atom transfer with transient iminyl copper species.