127605-76-9

Basic information

• Product Name: C₁₂H₂₄O₆*C₄H₈N₂O₃*ClH
• Synonyms: C₁₂H₂₄O₆*C₄H₈N₂O₃*ClH
• CAS NO: 127605-76-9
• Molecular Weight: 432.899
• Mol File: 127605-76-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₂H₂₄O₆*C₄H₈N₂O₃*ClH(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₂₄O₆*C₄H₈N₂O₃*ClH(127605-76-9)
• EPA Substance Registry System: C₁₂H₂₄O₆*C₄H₈N₂O₃*ClH(127605-76-9)

Safety Data

• Hazardous Substances Data: 127605-76-9(Hazardous Substances Data)

Upstream product

• 17455-13-9 18-crown-6 ether 
• 556-50-3 glycylglycine 

Downstream Products

• 2387-23-7 1,3-Dicyclohexylurea 
• 106-57-0 Glycine anhydride 

Relevant articles and documents

The Use of Crown Ethers in Peptide Chemistry. Part 2. Syntheses of Dipeptide Complexes with Cyclic Polyether 18-Crown-6 and their Derivatisation with DMSO

As part of a study the aim of which is to use crown compounds as non-covalent protecting groups in peptide synthesis, we have explored the reactivity of 18-crown-6-ether-dipeptide complexes with dicyclohexylcarbodi-imide (DCC) in dimethyl sulphoxide (DMSO).At a reactant concentration of ca. 0.02 mol dm-3 the DCC did not activate the dipeptide, and the N-acylurea derivative slowly formed.At concentrations of ca. 0.2 mol dm-3 the complexes proved to be unstable and reacted with the solvent to form a DMSO-peptide adduct.The reaction mechanism leading to the latter was elucidated and shown to involve an initial acid-catalysed addition of DMSO to DCC.The presence in solution of nucleophiles gave the peptide ester thus indicating DCC-mediated activation of the peptide carboxylic acid group.The results from this study were used to design the conditions necessary for an effective non-covalent protection of the amino group during peptide synthesis.