1276111-41-1Relevant articles and documents
Enantioselective α-arylation of aldehydes via the productive merger of iodonium salts and organocatalysis
Allen, Anna E.,MacMillan, David W. C.
supporting information; experimental part, p. 4260 - 4263 (2011/06/21)
The enantioselective α-arylation of aldehydes has been accomplished using diaryliodonium salts and a combination of copper and organic catalysts. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-formyl benzylic stereocenters, a valuable synthon for the production of medicinal agents. As one example, this new asymmetric protocol has been applied to the rapid synthesis of (S)-ketoprofen, a commercially successful oral and topical analgesic.