1276656-59-7

Basic information

• Product Name: 2-{6-[2-amino-5-(trifluoromethyl)phenyl]pyridazin-3-yl}-4-(trifluoromethyl)aniline
• Synonyms: 2-{6-[2-amino-5-(trifluoromethyl)phenyl]pyridazin-3-yl}-4-(trifluoromethyl)aniline
• CAS NO: 1276656-59-7
• Molecular Weight: 398.31
• Mol File: 1276656-59-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-{6-[2-amino-5-(trifluoromethyl)phenyl]pyridazin-3-yl}-4-(trifluoromethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{6-[2-amino-5-(trifluoromethyl)phenyl]pyridazin-3-yl}-4-(trifluoromethyl)aniline(1276656-59-7)
• EPA Substance Registry System: 2-{6-[2-amino-5-(trifluoromethyl)phenyl]pyridazin-3-yl}-4-(trifluoromethyl)aniline(1276656-59-7)

Safety Data

• Hazardous Substances Data: 1276656-59-7(Hazardous Substances Data)

Upstream product

• 57946-63-1 4-amino-3-bromobenzotrifluoride 
• 17973-86-3 3,6-dibromopyridazine 
• 1058062-64-8 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)benzenamine 

Downstream Products

• 1276656-76-8 tert-butyl N-{2-[(2-{6-[2-(3-{[(tert-butoxy)carbonyl]amino}propanamido)-5-(trifluoromethyl)phenyl]pyridazin-3-yl}-4-(trifluoromethyl)phenyl)carbamoyl]ethyl}carbamate 
• 1276656-66-6 N-(2-{6-[2-acetamido-5-(trifluoromethyl)phenyl]pyridazin-3-yl}-4-(trifluoromethyl)phenyl)acetamide 

Relevant articles and documents

Synthetic mimics of antimicrobial peptides from triaryl scaffolds

In this report, we describe the synthesis of a new series of small amphiphilic aromatic compounds that mimic the essential properties of cationic antimicrobial peptides using Suzuki-Miyaura coupling. The new design allowed the easy tuning of the conformational restriction, controlled by introduction of intramolecular hydrogen bonds, and the overall hydrophobicity by modifications to the central ring and the side chains. This approach allowed us to better understand the influence of these features on the antimicrobial activity and selectivity. We found that the overall hydrophobicity had a more significant impact on antimicrobial and hemolytic activity than the conformational stiffness. A novel compound was discovered which has MICs of 0.78 μg/mL against S. Aureus and 6.25 μg/mL against E. Coli, similar to the well-known antimicrobial peptide, MSI-78.