1276668-47-3

Basic information

• Product Name: 2'-O-(2-Trifluoromethyl-3,3,3-trifluoropropanoxymethyl)-5'-O-(4,4'-dimethoxytrityl)uridine
• Synonyms: 2'-O-(2-Trifluoromethyl-3,3,3-trifluoropropanoxymethyl)-5'-O-(4,4'-dimethoxytrityl)uridine
• CAS NO: 1276668-47-3
• Molecular Weight: 740.653
• Mol File: 1276668-47-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2'-O-(2-Trifluoromethyl-3,3,3-trifluoropropanoxymethyl)-5'-O-(4,4'-dimethoxytrityl)uridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-O-(2-Trifluoromethyl-3,3,3-trifluoropropanoxymethyl)-5'-O-(4,4'-dimethoxytrityl)uridine(1276668-47-3)
• EPA Substance Registry System: 2'-O-(2-Trifluoromethyl-3,3,3-trifluoropropanoxymethyl)-5'-O-(4,4'-dimethoxytrityl)uridine(1276668-47-3)

Safety Data

• Hazardous Substances Data: 1276668-47-3(Hazardous Substances Data)

Upstream product

• 1276668-46-2 2'-O-(2-Trifluoromethyl-3,3,3-trifluoropropanoxymethyl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 174497-93-9 2'-O-methylthiomethyl-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine 
• 1276668-48-4 2'-O-(2-trifluoromethyl-3,3,3-trifluoropropanoxymethyl)uridine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 81246-79-9 5'-dimethoxytrityluridine 
• 820212-19-9 2′,3′-O-bis-(benzyloxycarbonyl)uridine 

Relevant articles and documents

NOVEL PROTECTING GROUP FOR SYNTHESIZING RNA AND DERIVATIVE THEREOF

A protective group represented by the following general formula (I) (the oxygen atom attached with * represents oxygen atom of 2'-hydroxyl group of a ribonucleoside, a ribonucleotide or a derivative thereof, R1 and R2 both represent hydrogen atom, or represent a halogen atom, a C1-6 alkyl group, or a C1-6 halo-substituted alkyl group; R3 and R4 represent hydrogen atom, a halogen atom, a C1-6 alkyl group, or a C1-6 halo-substituted alkyl group; and R5 and R6 represent a halogen atom, a C1-6 halo-substituted alkyl group, cyano group, nitro group, or the like), which is stable under the reaction conditions of the nucleic acid synthetic cycles and has little steric hindrance, and can be removed under mild conditions using fluoride ions as a base.