1276688-15-3Relevant articles and documents
Asymmetric michael addition of 1-acetylindolin-3-ones to β-nitrostyrenes catalyzed by bifunctional thioureas: A simple access to 2-functionalized indoles
Liu, Yao-Zong,Cheng, Rui-Ling,Xu, Peng-Fei
supporting information; experimental part, p. 2884 - 2887 (2011/06/17)
The first asymmetric Michael addition of 1-acetylindolin-3-ones to β-nitrostyrenes has been developed. 2-Substituted indolin-3-one derivatives were obtained with excellent yields (up to 99%) and good stereoselectivities (up to 28:1 dr and 92% ee), which could be transformed into 2-functionalized indoles easily without racemization. This achievement might further contribute to the chemistry and pharmacology of indole-related compounds.