127686-61-7 Usage
Description
(1R,4R)-BIS[(2-METHOXYPHENYL)PHENYLPHOSPHINO]BUTANE, also known as (R,R)-MeOBIPHEP, is a chiral diphosphine ligand that plays a crucial role in transition metal-catalyzed reactions. It features two methoxyphenyl groups and one phenylphosphino group attached to a butane backbone, which allows it to control the stereochemistry of the reactions it participates in. This unique structure makes it a valuable tool in organic synthesis.
Uses
Used in Pharmaceutical Industry:
(1R,4R)-BIS[(2-METHOXYPHENYL)PHENYLPHOSPHINO]BUTANE is used as a chiral ligand in asymmetric catalysis for the synthesis of various pharmaceuticals and fine chemicals. Its effectiveness in metal-catalyzed asymmetric hydrogenation reactions and a wide range of metal-catalyzed transformations, including carbon-carbon bond formations, makes it a key component in the production of enantiomerically pure compounds, which are essential in the development of many drugs.
Used in Organic Synthesis:
In the field of organic synthesis, (1R,4R)-BIS[(2-METHOXYPHENYL)PHENYLPHOSPHINO]BUTANE is used as a chiral ligand to control the stereochemistry of reactions. This ability to dictate the spatial arrangement of atoms in a molecule is crucial for the synthesis of complex organic compounds, including those with potential applications in materials science, agrochemicals, and other specialty chemical industries.
Check Digit Verification of cas no
The CAS Registry Mumber 127686-61-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,6,8 and 6 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 127686-61:
(8*1)+(7*2)+(6*7)+(5*6)+(4*8)+(3*6)+(2*6)+(1*1)=157
157 % 10 = 7
So 127686-61-7 is a valid CAS Registry Number.
127686-61-7Relevant articles and documents
Synthesis and reactions of phosphine-boranes. Synthesis of new bidentate ligands with homochiral phosphine centers via optically pure phosphine-boranes
Imamoto, Tsuneo,Oshiki, Toshiyuki,Onozawa, Takashi,Kusumoto, Tetsuo,Sato, Kazuhiko
, p. 5244 - 5252 (2007/10/02)
Secondary and tertiary phosphine-boranes were synthesized in one-pot from phosphine oxides or substituted chlorophosphines without isolation of the intermediate phosphines. Phosphine-boranes having a methyl group were metalated with sec-butyllithium. The generated carbanions reacted with alkyl halides or carbonyl compounds to yield various phosphine-borane derivatives. The carbanions underwent copper(II)-promoted oxidative coupling without impairment of the borane functionality. Secondary phosphine-boranes reacted with alkyl halides, aldehydes, or α,β-unsaturated carbonyl compounds to give phosphine-borane derivatives having a functional group. The boranato group of phosphine-boranes was removed in a stereospecific manner with retention of configuration by treatment with a large excess of amine such as morpholine. A new route to bidentate ligands with homochiral phosphine centers has been explored by utilizing these characteristic reactivities of phosphine-boranes. Thus, optically pure (S,S)-1,2-bis(o-anisylphenylphosphino)ethane, (R,R)-1,2-bis(tert-butylphenyl-phosphino)ethane, and (S,S)-1,4-bis(o-anisylphenylphosphino)butane have been synthesized via phosphine-boranes.
