127744-28-9Relevant articles and documents
Total Synthesis of the Cyclic Depsipeptide Vioprolide D via its (Z)-Diastereoisomer
Bach, Thorsten,Grab, Hanusch A.,Kirsch, Volker C.,Sieber, Stephan A.
supporting information, p. 12357 - 12361 (2020/05/05)
The first total synthesis of vioprolide D was accomplished in an overall yield of 2.0 % starting from methyl (2S)-3-benzyloxy-2-hydroxypropanoate (16 steps in the longest linear sequence). The cyclic depsipeptide was assembled from two building blocks of
JAK1 SELECTIVE INHIBITORS
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, (2018/08/12)
Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1-R8 have any of the meanings defined herein. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I) and methods of using the same.
POLYMYXIN ANALOGS USEFUL AS ANTIBIOTIC POTENTIATORS
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, (2017/12/09)
The disclosure provides compounds of the formula (I) or a tautomer thereof, or a pharmaceutically acceptable salt of either of the foregoing. The variables A, R1, and R2 are defined in the disclosure. The disclosure further includes pharmaceutical compositions comprising a compound of formula I together with at least one pharmaceutically acceptable carrier. The disclosure also includes a method of sensitizing bacteria to an antibacterial agent, comprising administering to a patient infected with the bacteria, simultaneously or sequentially, a therapeutically effective amount of the antibacterial agent and a compound of formula (I).