127757-91-9

Basic information

• Product Name: Regramostim
• Synonyms: CSF-2;Regramostim;Colony-stimulating factor 2 (human clone pcsf-1 protein moiety reduced), glycoform gmc 89-107;Regramostime;Regramostime [inn-french];Regramostimum;Regramostimum [inn-latin];GM-CSF from mouse
• CAS NO: 127757-91-9
• Molecular Weight: 0
• Mol File: 127757-91-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C
• CAS DataBase Reference: Regramostim(CAS DataBase Reference)
• NIST Chemistry Reference: Regramostim(127757-91-9)
• EPA Substance Registry System: Regramostim(127757-91-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/38
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 127757-91-9(Hazardous Substances Data)

Usage

Description

Regramostim, also known as GM-CSF (granulocyte-macrophage colony-stimulating factor), is a 14.2kDa globular protein consisting of 124 amino acid residues. It is produced by various cells, including endothelial cells, monocytes, fibroblasts, and T-lymphocytes. Regramostim is a hematopoietic stimulant that promotes the growth and differentiation of neutrophils and macrophages, playing a crucial role in the immune system.

Uses

Used in Antineutropenic Applications:
Regramostim is used as an antineutropenic agent for the treatment of neutropenia, a condition characterized by an abnormally low number of neutrophils in the blood. It stimulates the production and differentiation of neutrophils, helping to increase their count and improve the body's immune response.
Used in Hematopoietic Stimulation:
Regramostim is used as a hematopoietic stimulant to promote the growth and differentiation of various blood cells, including neutrophils and macrophages. This application is particularly useful in patients undergoing chemotherapy or radiation therapy, as these treatments can lead to a decrease in blood cell production.
Used in Retinal Ganglion Cell Neuroprotection:
In the field of neuroscience, Regramostim has been used as a growth factor to study its effects on retinal ganglion cell neurite outgrowth in retinal explants. This application aims to understand the potential of Regramostim in promoting nerve cell growth and protection, which could be beneficial in treating conditions like glaucoma or other retinal diseases.
Used in Pharmaceutical Industry:
Regramostim is used as a therapeutic agent in the pharmaceutical industry for the treatment of various conditions related to neutropenia and immune system dysfunction. Its role as a hematopoietic stimulant makes it a valuable asset in the development of treatments for patients with compromised immune systems or those undergoing intensive medical treatments.

Biochem/physiol Actions

GM-CSF (granulocyte-macrophage colony-stimulating factor, also referred to as CSF2) is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It enhances neutrophil migration. GM-CSF plays a crucial role in inflammatory and autoimmune diseases. In neutrophils, it promotes the expression of TLR2 (Toll-like receptor) and TLR2-associated interleukin 8 responses, thereby eliminating microbial attack.