127798-61-2

Basic information

• Product Name: 1-(1-trityl-1H-imidazol-4-yl)-prop-2-en-1-ol
• Synonyms: 1-(1-trityl-1H-imidazol-4-yl)-prop-2-en-1-ol
• CAS NO: 127798-61-2
• Molecular Weight: 366.462
• Mol File: 127798-61-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(1-trityl-1H-imidazol-4-yl)-prop-2-en-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-trityl-1H-imidazol-4-yl)-prop-2-en-1-ol(127798-61-2)
• EPA Substance Registry System: 1-(1-trityl-1H-imidazol-4-yl)-prop-2-en-1-ol(127798-61-2)

Safety Data

• Hazardous Substances Data: 127798-61-2(Hazardous Substances Data)

Upstream product

• 3034-50-2 5-imidazolecarboxaldehyde 
• 1826-67-1 vinyl magnesium bromide 
• 76-83-5 trityl chloride 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 
• 96797-15-8 N-trityl-4⁽⁵⁾-iodoimidazole 
• 107-02-8 acrolein 
• 33769-07-2 4-(hydroxymethyl)-1-(triphenylmethyl)imidazole 

Downstream Products

• 131120-96-2 (5S,6R)-5-Chloro-2-trichloromethyl-6-(1-trityl-1H-imidazol-4-yl)-5,6-dihydro-4H-[1,3]oxazine 
• 131121-00-1 2,2,2-Trichloro-N-[1-(1-trityl-1H-imidazol-4-yl)-allyl]-acetamide 
• 127822-76-8 (+/-)-erythro-β-chloro-γ-hydroxy-1-triphenylmethyl-1H-4-imidazolepropanamine 
• 127798-64-5 Acetic acid 1-(tert-butoxycarbonylamino-methyl)-2-(tert-butyl-dimethyl-silanyloxy)-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester 
• 127798-64-5 Acetic acid 1-(tert-butoxycarbonylamino-methyl)-2-(tert-butyl-dimethyl-silanyloxy)-2-(1-trityl-1H-imidazol-4-yl)-ethyl ester 
• 127798-66-7 [3-(tert-Butyl-dimethyl-silanyloxy)-2-chloro-3-(1-trityl-1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester 
• 127798-66-7 [3-(tert-Butyl-dimethyl-silanyloxy)-2-chloro-3-(1-trityl-1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester 
• 127798-63-4 [3-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester 
• 127798-63-4 [3-(tert-Butyl-dimethyl-silanyloxy)-2-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester 
• 127798-69-0 3-Amino-1-[2-(4-bromo-phenylazo)-1H-imidazol-4-yl]-2-chloro-propan-1-ol 
• 127798-69-0 3-Amino-1-[2-(4-bromo-phenylazo)-1H-imidazol-4-yl]-2-chloro-propan-1-ol 
• 110883-46-0 girolline 
• 110883-46-0 3-Amino-1-(2-amino-1H-imidazol-4-yl)-2-chloro-propan-1-ol 
• 134509-70-9 [3-(tert-Butyl-diphenyl-silanyloxy)-2-hydroxy-3-(1-trityl-1H-imidazol-4-yl)-propyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

COMPOUND, COMPOSITIONS, AND METHODS

Compounds having activity as LRRK2 inhibitors are disclosed. The compounds are of formula (I) including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

A Facile Route to Imidazol-4-yl Anions and Their Reaction with Carbonyl Compounds

Treatment of N-protected 4-iodoimidazoles 1-3 in CH2Cl2 solution with an etheral solution of ethylmagnesium bromide generates the corresponding imidazol-4-yl anions, which react with carbonyl compounds to give carbinols 4-14 in 60-83percent yield.

PREMIERE SYNTHESE TOTALE DE GIROLLINE

Isolated from a Sponge, girolline is an 2-amino imidazole derivative with significant antitumoral activity.Its total synthesis is described for the first time in this communication.