1279093-54-7

Basic information

• Product Name: C₁₂H₁₂BrFN₂O₂S
• Synonyms: C₁₂H₁₂BrFN₂O₂S
• CAS NO: 1279093-54-7
• Molecular Weight: 347.208
• Mol File: 1279093-54-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₂BrFN₂O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₂BrFN₂O₂S(1279093-54-7)
• EPA Substance Registry System: C₁₂H₁₂BrFN₂O₂S(1279093-54-7)

Safety Data

• Hazardous Substances Data: 1279093-54-7(Hazardous Substances Data)

Upstream product

• 210240-20-3 4-aminotetrahydro-2H-thiopyran-1,1-dioxide 
• 123843-67-4 4-bromo-2,6-difluorobenzonitrile 

Downstream Products

• 1279091-35-8 C₂₆H₂₈FN₃O₄S 
• 1279093-55-8 C₁₂H₁₄BrFN₂O₃S 

Relevant articles and documents

HSP-90 BINDING COMPOUNDS, COMPOSITIONS THEREOF, AND THEIR USE IΝ THE TREATMENT AND PREVENTION OF FUNGAL INFECTIONS

The invention relates to therapeutic compounds that bind to HSP90. The compounds disclosed herein bind HSP90 and alter the chaperoning capability of HSP90 proteins. The invention also relates to pharmaceutical compositions comprising these compounds, and methods of treating or preventing fungal infections.

HSP90 MODULATING COMPOUNDS, COMPOSITIONS, METHODS AND USES

The invention relates to therapeutic compounds which bind to HSP90, said compounds containing a benzamide group bound to a tricyclic condensed ring system via the nitrogen atom of a pyrrole located in the center of the condensed system. The compounds disclosed herein bind HSP90 and alter the chaperoning capability of HSP90 proteins. Intermediate benzonitrile compounds which are precursors to the benzamide compounds are also disclosed. The invention also relates to pharmaceutical compositions comprising these compounds, and methods of treating diseases and disorders such as cancer, autoimmune diseases and other diseases.