127958-63-8

Basic information

• Product Name: 6-MethylMorpholin-3-one
• Synonyms: 6-MethylMorpholin-3-one;6-methyl-3-morpholinone;rac 6-Methyl-morpholin-3-one, 98%
• CAS NO: 127958-63-8
• Molecular Formula: C5H9NO2
• Molecular Weight: 115.13046
• Mol File: 127958-63-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-MethylMorpholin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-MethylMorpholin-3-one(127958-63-8)
• EPA Substance Registry System: 6-MethylMorpholin-3-one(127958-63-8)

Safety Data

• Hazardous Substances Data: 127958-63-8(Hazardous Substances Data)

Upstream product

• 2799-16-8 (2R)-hydroxypropylamine 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 1335138-72-1 2-[(1R)-2-amino-1-methylethoxy]-3-[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]propionic acid 
• 1335139-83-7 (6R)-4-(methoxymethyl)-6-methyl-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}morpholin-3-one 
• 1335139-84-8 C₁₈H₂₉N₃O₄ 
• 790184-33-7 (2R)-2-methyl-morpholine 
• 74572-13-7 (2S)-2-methyl-morpholine 
• 27550-90-9 2-methylmorpholine 
• 1605312-12-6 (2R,5S)-4-{2-[6-(4-fluoro-benzyl)-3,3-dimethyl-2,3-dihydro-pyrrolo[3,2-b]pyridin-1-yl]-2-oxo-ethyl}-2-methyl-5-((R)-2-methyl-5-oxo-morpholin-4-ylmethyl)-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

INHIBITORS OF WDR5 PROTEIN-PROTEIN BINDING

The present application is directed to compounds of Formula I: compounds comprising these compounds and their uses, for example as medicaments for the treatment of diseases, disorders or conditions mediated or treatable by inhibition of binding between WDR5 protein and its binding partners.

A concise and efficient synthesis of substituted morpholines

A simple and efficient method has been developed for the synthesis of substituted morpholines by a sequence of coupling, cyclization, and reduction reactions of easily available amino alcohols and α-halo acid chlorides. Various mono-, di-, and trisubstituted morpholines, spiro morpholines, and ring-fused morpholines, as well as morpholine homologues, were synthesized in good to excellent yields by a single methodology under similar reaction conditions. The method was also used in a multigram synthesis of (3S)-3-methylmorpholine.