127977-24-6

Basic information

• Product Name: L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-methyl-, phenylmethyl ester
• CAS NO: 127977-24-6
• Molecular Formula: C22H27NO4
• Molecular Weight: 369.461
• Mol File: 127977-24-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-methyl-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-methyl-, phenylmethyl ester(127977-24-6)
• EPA Substance Registry System: L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-methyl-, phenylmethyl ester(127977-24-6)

Safety Data

• Hazardous Substances Data: 127977-24-6(Hazardous Substances Data)

Upstream product

• 100-51-6 benzyl alcohol 
• 80102-27-8 (2S)-3-(4-methylphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid 
• 94882-74-3 benzyl 2(S)-(tert-butoxycarbonylamino)-3-p-toluenesulfonylpropionate 
• 59524-02-6 N-tert-butoxycarbonyl-L-serine benzyl ester 
• 3695-68-9 L-serine benzyl ester benzenesulfonate salt 
• 24424-99-5 di-tert-butyl dicarbonate 
• 624-31-7 4-tolyl iodide 
• 108957-20-6 (R)-N-(tert-butoxycarbonyl)-3-iodoalanine benzyl ester 

Downstream Products

• 1427856-58-3 C₁₇H₁₉NO₂ 

Relevant articles and documents

Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes

A systematic study of P2 and P3 substitution in a series of vinyl sulfone cysteine protease inhibitors is described. The introduction of a methyl substituent in the P2 phenylalanine aryl ring had a favorable effect on protease inhibition and conferred modest selectivity for rhodesain over cruzain. Rhodesain selectivity could be enhanced further by combining these P2 modifications with certain P3 amide substituents.

SYNTHESIS OF ENANTIOMERICALLY PURE PROTECTED β-ARYL ALANINES

The organozinc reagent (1), prepared from the β-iodoalanine derivative (2), reacts with aryl iodides at 50 deg C in the presence of catalytic bis(tri-o-tolylphosphine)palladium dichloride to give in moderate to good yields enantiomerically pure protected