127978-35-2

Basic information

• Product Name: 3-(3-bromopropionylamino)-2-methyl-4-(3-nitrophenyl)-6-phenylpyridine
• Synonyms: 3-(3-bromopropionylamino)-2-methyl-4-(3-nitrophenyl)-6-phenylpyridine
• CAS NO: 127978-35-2
• Molecular Weight: 440.296
• Mol File: 127978-35-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(3-bromopropionylamino)-2-methyl-4-(3-nitrophenyl)-6-phenylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-bromopropionylamino)-2-methyl-4-(3-nitrophenyl)-6-phenylpyridine(127978-35-2)
• EPA Substance Registry System: 3-(3-bromopropionylamino)-2-methyl-4-(3-nitrophenyl)-6-phenylpyridine(127978-35-2)

Safety Data

• Hazardous Substances Data: 127978-35-2(Hazardous Substances Data)

Upstream product

• 127978-25-0 3-tert-butyloxycarbonylamino-2-methyl-4-(3-nitrophenyl)-6-phenylpyridine 
• 113293-86-0 2-methyl-4-(3-nitrophenyl)-6-phenyl-3-pyridinecarboxylic acid 
• 7623-16-7 3-bromopropionyl bromide 
• 127978-29-4 3-amino-2-methyl-4-(3-nitrophenyl)-6-phenylpyridine 

Relevant articles and documents

Studies on cerebral protective agents. V. Novel 4-(3-nitrophenyl)pyridine and 4-(3-nitrophenyl)pyrimidine derivatives with anti-anoxic activity

Novel 4-(3-nitrophenyl)pyridine and 4-(3-nitrophenyl)pyrimidine derivatives, possessing three-atom linkages between basic nitrogen and at the C-5 (or C-3) position of the pyrimidine (or pyridine) ring, were synthesized and tested for anti-anoxic (AA) activity in mice. Among them, 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-(pyrrolidinomethylcarbonylamino) pyrimidine (10f) had the most potent AA activity (3.2 mg/kg, i.p.). Three-dimensional molecular electrostatic potentials (3D-MEP) around the nitrogeneous basic moiety of 6-methyl-5-(4-methylpiperazin-1-ylcarbonyl)-4-(3-nitrophenyl)-2-phenyl pyrimidine (FK 360) and 10f were compared. The negative zone of 10f is broader and deeper and positioned somewhat differently to that of FK 360, although there is a co-occupied spacial area in part.