128-19-8

Basic information

• Product Name: 4-Pregnene-17,20beta,21-triol-3-one
• Synonyms: 4-Pregnene-17,20beta,21-triol-3-one;4-pregnene-17alpha,20beta,21-triol-3-one;4-Pregnene-17a,20b,21-triol-3-one
• CAS NO: 128-19-8
• Molecular Formula: C₂₁H₃₂O₄
• Molecular Weight: 348.47638
• Mol File: 128-19-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Pregnene-17,20beta,21-triol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pregnene-17,20beta,21-triol-3-one(128-19-8)
• EPA Substance Registry System: 4-Pregnene-17,20beta,21-triol-3-one(128-19-8)

Safety Data

• Hazardous Substances Data: 128-19-8(Hazardous Substances Data)

Upstream product

• 444083-52-7 21-acetoxy-3-ethoxy-16α,17-epoxy-pregna-3,5-dien-20-one 
• 152-58-9 Cortexolone 

Downstream Products

• 64-85-7 21-Hydroxyprogesterone 

Relevant articles and documents

A biocatalytic hydroxylation-enabled unified approach to C19-hydroxylated steroids

Steroidal C19-hydroxylation is pivotal to the synthesis of naturally occurring bioactive C19-OH steroids and 19-norsteroidal pharmaceuticals. However, realizing this transformation is proved to be challenging through either chemical or biological synthesis. Herein, we report a highly efficient method to synthesize 19-OH-cortexolone in 80% efficiency at the multi-gram scale. The obtained C19-OH-cortexolone can be readily transformed to various synthetically useful intermediates including the industrially valuable 19-OH-androstenedione, which can serve as a basis for synthesis of C19-functionalized steroids as well as 19-nor steroidal drugs. Using this biocatalytic C19-hydroxylation method, the unified synthesis of six C19-hydroxylated pregnanes is achieved in just 4 to 9 steps. In addition, the structure of sclerosteroid B is revised on the basis of our synthesis.

Asymmetric reduction of steroidal 20-ketones: Chemical synthesis of corticosteroid derivatives containing the 20α, 21-diol and 17α, 20α, 21-triol side chains

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