128-33-6 Usage
Description
5-alpha-cholesta-8,24-dien-3-beta-ol, also known as zymosterol, is a sterol intermediate in the biosynthesis of cholesterol (C432501). It plays a crucial role in the production of cholesterol, which is a vital component of all biological membranes, including the brain, where it constitutes approximately 25% of the total lipid content. Zymosterol has been identified in the plasma membrane of cultured human fibroblasts through labeling studies.
Uses
Used in Pharmaceutical Industry:
5-alpha-cholesta-8,24-dien-3-beta-ol is used as a key intermediate in the synthesis of cholesterol for various pharmaceutical applications. Cholesterol serves as a fundamental component of biological membranes, providing structural integrity and regulating the passage of molecules across the membrane. It also plays a role in the production of essential hormones and bile acids.
Used in Research and Development:
5-alpha-cholesta-8,24-dien-3-beta-ol is utilized as a research tool for studying the biosynthesis of cholesterol and its role in various cellular processes. Understanding the function and regulation of zymosterol can contribute to the development of targeted therapies for conditions related to cholesterol metabolism and homeostasis.
Used in Cell Biology:
In cell biology, 5-alpha-cholesta-8,24-dien-3-beta-ol is used as a marker for the plasma membrane of cultured human fibroblasts. This application aids in the study of membrane dynamics, cellular processes, and the role of cholesterol in cellular functions.
Used in Drug Delivery Systems:
Although not explicitly mentioned in the provided materials, zymosterol could potentially be used in the development of drug delivery systems, similar to gallotannin, to improve the delivery, bioavailability, and therapeutic outcomes of cholesterol-lowering drugs or other compounds targeting cholesterol-related pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 128-33-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 8 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 128-33:
(5*1)+(4*2)+(3*8)+(2*3)+(1*3)=46
46 % 10 = 6
So 128-33-6 is a valid CAS Registry Number.
InChI:InChI=1/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h7,19-21,23-24,28H,6,8-17H2,1-5H3/t19-,20+,21+,23-,24+,26+,27-/m1/s1
128-33-6Relevant articles and documents
A new synthesis of zymosterol
Baranovskii,Litvinovskaya,Khripach
, p. 250 - 256 (2007/10/03)
A modified scheme for the synthesis of zymosterol, one of the biosynthetically important yeast sterols, starting from 3-benzoyloxyergosta-8(14),22-dien-15-one has been suggested.
Synthesis of Zymosterol: Salient Intermediate of Fungal and Mammalian Sterol Biosynthesis
Dolle, Roland E.,Schmidt, Stanley J.,Kruse, Lawrence I.
, p. 19 - 21 (2007/10/02)
A useful strategy for the construction of sterol biosynthetic intermediates possessing Δ8-unsaturation is described and exemplified by the synthesis of zymosterol (1) and 24,25-dihydrozymosterol (2).