128-49-4

Basic information

• Product Name: DOCUSATE CALCIUM (500 MG)
• Synonyms: DOCUSATE CALCIUM (500 MG);calcium 1,4-bis(2-ethylhexyl) bis(2-sulphosuccinate);calcium dioctyl sulfosuccinate;Bis[1,2-bis[(2-ethylhexyl)oxycarbonyl]ethanesulfonic acid] calcium salt;Bis[1-[[(2-ethylhexyl)oxy]carbonyl]-3-oxo-3-(2-ethylhexyloxy)propane-1-sulfonic acid] calcium salt;Bis[3-sulfosuccinic acid 1,4-bis(2-ethylhexyl)]calcium salt;Butanedioic acid,2-sulfo-, 1,4-bis(2-ethylhexyl) ester, calciuM salt (2:1);Butanedioicacid,sulfo-,1,4-bis(2-ethylhexyl)ester,calciumsalt
• CAS NO: 128-49-4
• Molecular Formula: C40H74CaO14S2
• Molecular Weight: 883.21516
• EINECS: 204-889-8
• Mol File: 128-49-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0Pa at 20℃
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly, Heated), Methanol (Slightly)
• Water Solubility: 6g/L at 20℃
• Stability: Hygroscopic
• CAS DataBase Reference: DOCUSATE CALCIUM (500 MG)(CAS DataBase Reference)
• NIST Chemistry Reference: DOCUSATE CALCIUM (500 MG)(128-49-4)
• EPA Substance Registry System: DOCUSATE CALCIUM (500 MG)(128-49-4)

Safety Data

• Hazardous Substances Data: 128-49-4(Hazardous Substances Data)

Usage

Description

DOCUSATE CALCIUM (500 MG) is a calcium salt derived from the compound docusate, which is primarily used as a stool softener and laxative. It functions by reducing the surface tension of water in the intestines, allowing for easier passage of stool and relieving constipation. This medication is available under the brand name Surfak, manufactured by Hoechst-Roussel.

Uses

Used in Pharmaceutical Industry:
DOCUSATE CALCIUM (500 MG) is used as a stool softener for the treatment of constipation. It helps to alleviate the discomfort and difficulty associated with passing stool by softening it, making it easier to expel.
Used in Over-the-counter Medications:
DOCUSATE CALCIUM (500 MG) is used as an active ingredient in various over-the-counter laxative and stool softener products. These products are designed to provide relief from constipation and promote regular bowel movements, making them accessible to individuals seeking a non-prescription solution for occasional constipation.

Originator

Surfak,Hoechst,US,1959

Manufacturing Process

88 g of dioctyl sodium sulfosuccinate is first dissolved in 100 cc of isopropanol and 25 g of calcium chloride is dissolved in 50 cc of methanol. The solutions are then mixed and stirred for about 3 hours and then cooled with ice. The sodium chloride which precipitates in the cool mixture is removed by filtration and most of the alcohol is evaporated from the resulting filtrate with heat. The liquid remaining is poured into 88 cc of water, and the resulting precipitate washed with water until free of chloride ion. The washed calcium salt is then dried.

Therapeutic Function

Stool softener

Flammability and Explosibility

Nonflammable

InChI:InChI=1/2C20H38O7S.Ca/c2*1-5-9-11-16(7-3)14-26-19(21)13-18(28(23,24)25)20(22)27-15-17(8-4)12-10-6-2;/h2*16-18H,5-15H2,1-4H3,(H,23,24,25);/q;;+2/p-2/rC40H74CaO14S2/c1-9-17-21-31(13-5)27-50-37(42)25-35(39(44)52-29-33(15-7)23-19-11-3)56(46,47)54-41-55-57(48,49)36(40(45)53-30-34(16-8)24-20-12-4)26-38(43)51-28-32(14-6)22-18-10-2/h31-36H,9-30H2,1-8H3