1280202-35-8Relevant articles and documents
Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy
Martínez González, Sonia,Rodríguez-Arístegui, Sonsoles,Hernández, Ana Isabel,Varela, Carmen,González Cantalapiedra, Esther,álvarez, Rosa María,Rodríguez Hergueta, Antonio,Bischoff, James R.,Albarrán, María Isabel,Cebriá, Antonio,Cendón, Elena,Cebrián, David,Alfonso, Patricia,Pastor, Joaquín
, p. 2536 - 2543 (2017/05/10)
The involvement of the phosphoinositide 3-kinases (PI3Ks) in several diseases, especially in the oncology area, has singled it as one of the most explored therapeutic targets in the last two decades. Many different inhibitor classes have been developed by