1280647-32-6

Basic information

• Product Name: (5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanol
• Synonyms: (5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanol
• CAS NO: 1280647-32-6
• Molecular Weight: 341.632
• Mol File: 1280647-32-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanol(1280647-32-6)
• EPA Substance Registry System: (5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanol(1280647-32-6)

Safety Data

• Hazardous Substances Data: 1280647-32-6(Hazardous Substances Data)

Usage

Description

(5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanol is a phenylmethanol compound that features a 5-bromo-2-chlorophenyl group and a 4-ethyloxyphenyl group attached to a methanol molecule. This unique structure may confer specific reactivity and properties that could be harnessed in various applications.

Uses

Used in Pharmaceutical Industry:
(5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanol is used as a potential pharmaceutical compound for its possible biological activity. Its specific reactivity and structural features may allow it to interact with biological targets, making it a candidate for drug development.
Used in Agrochemical Industry:
In the agrochemical field, (5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanol may serve as a component in the development of pesticides or other agricultural chemicals. Its chemical structure could provide pesticidal properties or enhance the effectiveness of existing agrochemicals.
Used as an Intermediate in Organic Synthesis:
(5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanol can be utilized as an intermediate in the synthesis of more complex organic compounds. Its unique functional groups may participate in various chemical reactions, facilitating the creation of a wide range of products.
Further analytical and experimental studies are required to fully understand the reactivity, toxicity, and other physical and chemical characteristics of (5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanol, which will ultimately determine its suitability and effectiveness in these and other potential applications.

Upstream product

• 103-73-1 Phenetole 
• 588-96-5 4-bromoethoxybenzene 
• 21739-92-4 5-bromo-2-chlorobenzoic acid 
• 41842-30-2 4-ethoxyphenylmagnesium bromide 
• 189628-37-3 2-chloro-5-bromobenzaldehyde 
• 21900-52-7 5-bromo-2-chloro-benzoyl chloride 
• 461432-22-4 (5-bromo-2-chlorophenyl)(4-ethyloxyphenyl)methanone 

Downstream Products

• 1298086-15-3 2-((benzyloxy)(4-ethoxyphenyl)methyl)-4-bromo-1-chlorobenzene 
• 1298086-16-4 2-(allyloxy(4-ethoxyphenyl)methyl)-4-bromo-1-chlorobenzene 
• 1318794-57-8 4-bromo-1-chloro-2-[(4-ethoxyphenyl)(methoxy)methyl]benzene 
• 1520113-11-4 4-bromo-1-chloro-2-(ethoxy(4-ethoxyphenyl)methyl)benzene 
• 1520113-13-6 4-bromo-1-chloro-2-((4-ethoxyphenyl)(isopropoxy)methyl)benzene 
• 1520113-15-8 4-bromo-2-(butoxy(4-ethoxyphenyl)methyl)-1-chlorobenzene 
• 1520113-17-0 4-bromo-1-chloro-2-((4-ethoxyphenyl)(phenethoxy)methyl)benzene 
• 1417573-74-0 1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucopyranoside 
• 915095-99-7 (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)tetrahydro-2H-pyran-3,4,5-trityl triacetate 
• 1079083-63-8 (2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-hydroxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF SOTAGLIFLOZIN

Sotagliflozin may be prepared using schemes and intermediates disclosed herein. Sotagliflozin may be incorporated into pharmaceutical dosage forms for treatment of diabetes.

Preparation methods of SGLT-2 diabetes inhibitors and intermediates thereof

The invention provides a preparation method of an intermediate compound 7 of an SGLT-2 diabetes inhibitor dapagliflozin and an intermediate compound 8 of a SGLT-2 diabetes inhibitor empagliflozin, and new synthesis method of two final products. The preparation method comprises the following steps: carrying out carbonyl group reduction and hydroxyl group protection on a (5-halo-2-chlorophenyl)(4-ethoxyphenyl)ketone compound 1 used as an initial raw material to obtain a Grignard addition reaction key compound 4, and carrying out Grignard addition and acetylation to obtain the compound 7 and the compound 8. The dapagliflozin and the empagliflozin are respectively prepared from the compound 8. The methods have the advantages of simplicity in operation, high yield, high purity of the obtained products, and suitableness for amplified production.

PHENYL C-GLUCOSIDE DERIVATIVES, PREPARATION METHODS AND USES THEREOF

The present invention relates to a sodium glucose cotransporter 2 (SGLT2) inhibitor with a phenyl C-glucoside structure, its preparation method, a pharmaceutical composition containing the same, and its use in treating diabetes and preparing an anti-diabetes medicament. The invention provides a compound with the structure of general formula I and a pharmaceutically acceptable salt and prodrug ester thereof, wherein, the definitions of R5 and R6 are selected from the following: (1) R5=R6=Me; (2) R5=Me, R6=OMe; (3) R5=Me, R6=H; (4) R5=Me, R6=F; (5) R5=F, R6=H; and (6) R5=OMe, R6=H.