1280725-52-1

Basic information

• Product Name: (S)-4-(naphthalen-2-yl)-4-p-tolylbutan-2-one
• CAS NO: 1280725-52-1
• Molecular Weight: 288.389
• Mol File: 1280725-52-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-4-(naphthalen-2-yl)-4-p-tolylbutan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-(naphthalen-2-yl)-4-p-tolylbutan-2-one(1280725-52-1)
• EPA Substance Registry System: (S)-4-(naphthalen-2-yl)-4-p-tolylbutan-2-one(1280725-52-1)

Safety Data

• Hazardous Substances Data: 1280725-52-1(Hazardous Substances Data)

Upstream product

• 66-99-9 β-naphthaldehyde 
• 5720-05-8 4-methylphenylboronic acid 
• 75032-63-2 4-(2-naphtalenyl)-3-buten-2-one 

Relevant articles and documents

Sequential aldol Condensation-Transition metal-Catalyzed addition reactions of aldehydes, methyl ketones, and arylboronic acids

Sequential aldol condensation of aldehydes with methyl ketones followed by transition metal-catalyzed addition reactions of arylboronic acids to form β-substituted ketones is described. By using the 1,1′;-spirobiindane- 7,7′;-diol (SPINOL)-based phosphite, an asymmetric version of this type of sequential reaction, with up to 92% ee, was also realized. Our study provided an efficient method to access β-substituted ketones and might lead to the development of other sequential/tandem reactions with transition metal-catalyzed addition reactions as the key step.