128073-16-5Relevant articles and documents
3 - chloro -5 - trifluoromethyl pyridine compounds and intermediates method (by machine translation)
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Paragraph 0095; 0096; 0097; 0098; 0099; 0100; 0101-0105, (2017/07/20)
The invention discloses a 3 - chloro -5 - trifluoromethyl pyridine compound and preparation method of the midbody. The invention of the formula 3 a compound represented by the preparation method, comprising the following steps: organic solvent and water in the mixed solvent, under the action of the phase transfer catalyst, shown as 2 shown with the metal cyanide compounds of the substitution reaction, carbonized 3 compound of formula; further comprises the following steps: in the solvent, under the effect of the fluorination reagent, shown as 1 shown in the fluorination reaction of the compound, prepared states like the type 2 compound of formula; and can also be further comprises the following steps: under the action of the hydrogen and ethanol, shown as 3 shown in the Pinner reaction compound, then hydrolyzing the ester reaction, carbonized 4 compounds are shown. The invention of 3 - chloro -5 - trifluoromethyl pyridine compound preparation method of low cost, high production safety, simple operation, high yield, it is suitable for industrial production. (by machine translation)
Herbicides
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, (2008/06/13)
Compounds of formula (I) in which A is ═N— or (a); W is a group (W1), (W2) or (W3); R11is hydrogen, fluorine, chlorine, bromine or methyl; and R1to R5, R13,n1and n13are as defined in claim 1, and the pyrazole N-oxydes, agrochemically tolerated salts and stereoisomers of these compounds of formula (I), have good pre- and post-emergent selective herbicidal properties. The preparation of these compounds and their use as herbidical active substances are described.
Synthetic process development and scale up of palladium-catalyzed alkoxycarbonylation of chloropyridines
Crettaz, Roger,Waser, Jerome,Bessard, Yves
, p. 572 - 574 (2013/09/07)
2,3-Dichloropyridines undergo a mono- or a dicarbonylation in the presence of carbon monoxide, an alcohol, and a palladium catalyst, affording selectively either alkyl 3-chloropyridine-2-carboxylates or dialkyl pyridine-2,3-dicarboxylates in good yields, depending on the reaction conditions. For instance, the process could be scaled up for the monoalkoxycarbonylation of 2,3-dichloro-5-(trifluoromethyl)pyridine, affording in high yield and selectivity the corresponding 3-chloro-5-(trifluoromethyl)pyridine-2-carboxylate.