128102-77-2Relevant articles and documents
Potent Affinity Labeling Peptide Inhibitors of Calpain
Matsueda, Rei,Umeyama, Hideaki,Puri, Rajinder N.,Bradford, Harlan N.,Colman, Robert W.
, p. 191 - 194 (2007/10/02)
We have employed a recently described affinity labeling approach using S-(3-nitro-2-pyridinesulfenyl) group (Npys) to devise unique inhibitors of the Ca++-dependent thiol protease, calpain.Compounds with Npys group bound on the peptides with Leu-Leu or Val-Val sequences were found to be highly potent inhibitors of calpain.