128156-57-0

Basic information

• Product Name: methyl 2-phenyl-4-benzoxazolecarboxylate
• Synonyms: methyl 2-phenyl-4-benzoxazolecarboxylate
• CAS NO: 128156-57-0
• Molecular Weight: 253.257
• Mol File: 128156-57-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl 2-phenyl-4-benzoxazolecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-phenyl-4-benzoxazolecarboxylate(128156-57-0)
• EPA Substance Registry System: methyl 2-phenyl-4-benzoxazolecarboxylate(128156-57-0)

Safety Data

• Hazardous Substances Data: 128156-57-0(Hazardous Substances Data)

Upstream product

• 89942-77-8 methyl 3-hydroxy-2-nitrobenzoate 
• 100-52-7 benzaldehyde 
• 17672-21-8 2-amino-3-hydroxy-benzoic acid methyl ester 
• 98-88-4 benzoyl chloride 
• 5333-86-8 ethyl benzimidate hydrochloride 
• 131862-25-4 2-phenylbenzo[d]oxazole-4-carboxylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 729589-52-0 3-hydroxy-2-[(2-phenyl-benzooxazole-4-carbonyl)-amino]-benzoic acid methyl ester 
• 729589-53-1 2-phenyl-benzooxazole-4-carboxylic acid (2-hydroxy-phenyl)-amide 
• 131862-25-4 2-phenylbenzo[d]oxazole-4-carboxylic acid 

Relevant articles and documents

Extending the scope of chromium - Manganese redox-coupled reactions: A one-pot synthesis of benzoxazoles

A critically important strategy for synthetic chemistry is the development of domino processes: those capable of concatenating multiple transformations into a single step. Such transformations not only provide an increase in synthetic efficiency, but also imply the development of a significant degree of mechanistic understanding. We report herein a new domino reaction, in which a chromium-manganese redox couple is employed both to catalytically reduce an o-hydroxy nitroarene and to oxidatively cyclize a subsequently formed imine. We find that the reaction is most effective for starting o-hydroxy nitroarenes with a strongly electron-withdrawing group at the para position.

Benzoxazoles as transthyretin amyloid fibril inhibitors: Synthesis, evaluation, and mechanism of action

Benzoxazoles pevent misfolding: Benzoxazole-based inhibitors of transthyretin (TTR) amyloid fibril formation are among the most effective found to date. They stabilize TTR against both acid-mediated misfolding and urea denaturation by raising the activati