128173-50-2 Usage
Description
N-(4-Cyanobutyl)-N-(phenylmethoxy)carbamic acid tert-butyl ester is an organic compound that serves as an intermediate in the synthesis of various pharmaceutical agents. It is characterized by its cyanobutyl and phenylmethoxy groups, which contribute to its reactivity and potential applications in medicinal chemistry.
Uses
Used in Pharmaceutical Synthesis:
N-(4-Cyanobutyl)-N-(phenylmethoxy)carbamic acid tert-butyl ester is used as an intermediate in the synthesis of Deferoxamine-d7 TFA Salt (D228982), a labelled Deferoxamine Mesylate (D228980). N-(4-Cyanobutyl)-N-(phenylmethoxy)carbamic acid tert-butyl ester is an iron chelating agent utilized in the therapy for patients with sickle cell diseases and iron overload conditions.
Used in Antioxidant and Neuroprotective Applications:
Studies suggest that N-(4-Cyanobutyl)-N-(phenylmethoxy)carbamic acid tert-butyl ester can exert potential antioxidant and neuroprotective effects in stroke patients. Its ability to chelate iron and modulate oxidative stress pathways may contribute to its therapeutic potential in neurodegenerative conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 128173-50-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,8,1,7 and 3 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 128173-50:
(8*1)+(7*2)+(6*8)+(5*1)+(4*7)+(3*3)+(2*5)+(1*0)=122
122 % 10 = 2
So 128173-50-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H24N2O3/c1-17(2,3)22-16(20)19(13-9-5-8-12-18)21-14-15-10-6-4-7-11-15/h4,6-7,10-11H,5,8-9,13-14H2,1-3H3
128173-50-2Relevant articles and documents
Design, Synthesis and Evaluation of AdSS Bisubstrate Inhibitors
Tibrewal, Nidhi,Elliott, Gregory I.
supporting information, p. 2269 - 2272 (2020/09/17)
Many cancers lack the expression of methylthioadenosine phosphorylase (MTAP). These cancers require adenylosuccinate synthetase (AdSS) for nucleic acid synthesis. By inhibiting adenylosuccinate synthetase, we potentially have a new therapeutic agent. Bisubstrate inhibitors were synthesized and evaluated against purified AdSS. The best activity was obtained with adenosine bearing a four-carbon linker that connects the N-formyl-N-hydroxy moiety to the 6-position of the purine nucleoside.
The synthesis of tetrahydropyridopyrimidones as a new scaffold for HIV-1 integrase inhibitors
Kinzel, Olaf D.,Monteagudo, Edith,Muraglia, Ester,Orvieto, Federica,Pescatore, Giovanna,Ferreira, Maria del Rosario Rico,Rowley, Michael,Summa, Vincenzo
, p. 6552 - 6555 (2008/02/12)
An efficient synthesis of methyl 9-amino-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-2-carboxylate as a late stage intermediate for a new class of HIV-1 integrase inhibitors is described. After construction of the bicyclic core scaffold,
Total synthesis of the siderophore Danoxamine
Roosenberg II, John M.,Miller, Marvin J.
, p. 4833 - 4838 (2007/10/03)
The total synthesis of the linear trihydroxamate siderophore, Danoxamine, is described. Danoxamine is a siderophore component of the naturally occurring siderophore-drug conjugates Salmycin A-D. The synthesis of Danoxamine features a series of coupling re