1282520-89-1

Basic information

• Product Name: 5-(2-methoxy-(1S)-methyl-ethoxy)isophthalic acid dimethyl ester
• Synonyms: 5-(2-methoxy-(1S)-methyl-ethoxy)isophthalic acid dimethyl ester
• CAS NO: 1282520-89-1
• Molecular Weight: 282.293
• Mol File: 1282520-89-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(2-methoxy-(1S)-methyl-ethoxy)isophthalic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-methoxy-(1S)-methyl-ethoxy)isophthalic acid dimethyl ester(1282520-89-1)
• EPA Substance Registry System: 5-(2-methoxy-(1S)-methyl-ethoxy)isophthalic acid dimethyl ester(1282520-89-1)

Safety Data

• Hazardous Substances Data: 1282520-89-1(Hazardous Substances Data)

Upstream product

• 4984-22-9 (R)-1-methoxy-2-propanol 
• 13036-02-7 Dimethyl 5-hydroxyisophthalate 

Downstream Products

• 1417648-28-2 C₂₅H₂₁F₃N₂O₅ 
• 1282520-12-0 3-[trans-2-(2,6-difluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide 
• 1282520-11-9 3-[trans-2-(2,5-difluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide 
• 1282520-10-8 3-[trans-2-(2,4-difluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide 
• 1282520-08-4 3-[trans-2-(4-fluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide 
• 1282520-07-3 3-[trans-2-(2-fluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide 
• 1417648-21-5 C₂₅H₂₃N₃O₇ 
• 1282520-06-2 3-[trans-2-(3-nitrophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide 
• 1282520-05-1 3-[trans-2-(2-nitrophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-6-yl)-benzamide 
• 1417648-15-7 C₂₆H₂₃F₃N₂O₅ 
• 1282519-99-6 3-[trans-2-(2,6-difluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide 
• 1282519-97-4 3-[trans-2-(2,5-difluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide 
• 1282519-95-2 3-[trans-2-(2,4-difluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotini c acid-3-methyl ester-6-yl)-benzamide 
• 1282519-91-8 3-[trans-2-(4-fluorophenyl)vinyl]-5-(2-methoxy-(1S)-methyl-ethoxy)-N-(nicotinic acid-3-methyl ester-6-yl)-benzamide 

Relevant articles and documents

Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus

Novel benzamide derivatives were synthesized and tested at in vitro assay by measuring fold increase of glucokinase activity at 5.0 mM glucose concentration. Among the prepared compounds, YH-GKA was found to be an active glucokinase activator with EC50 of 70 nM. YH-GKA showed similar glucose AUC reduction of 29.6% (50 mg/kg) in an OGTT study with C57BL/J6 mice compared to 29.9% for metformin (300 mg/kg). Acute treatment of the compound in C57BL/J6 and ob/ob mice elicited basal glucose lowering activity. In subchronic study with ob/ob mice, YH-GKA showed significant decrease in blood glucose levels and no adverse effects on serum lipids or body weight. In addition, YH-GKA exhibited high bioavailability and moderate elimination in preclinical species.