1282609-52-2

Basic information

• Product Name: C₂₅H₂₄O₁₁
• CAS NO: 1282609-52-2
• Molecular Weight: 500.459
• Mol File: 1282609-52-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₄O₁₁(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₄O₁₁(1282609-52-2)
• EPA Substance Registry System: C₂₅H₂₄O₁₁(1282609-52-2)

Safety Data

• Hazardous Substances Data: 1282609-52-2(Hazardous Substances Data)

Upstream product

• 154-23-4 catechin 
• 87292-54-4 (+)-(2R)-5,7-bis(benzyloxy)-2-[3,4-bis(benzyloxy)phenyl]chroman-3-one 
• 87292-49-7 5,7,3',4'-tetra-O-benzylepicatechin 
• 20728-73-8 5,7,3',4'-tetra-O-benzyl-(+)-catechin 
• 1282609-48-6 5,7,3',4'-tetra-O-benzyl-3-O-(3'',4'',5''-trimethoxybenzoyl)-(-)catechin 

Relevant articles and documents

Comparison of a Pair of Synthetic Tea-Catechin-Derived Epimers: Synthesis, Antifolate Activity, and Tyrosinase-Mediated Activation in Melanoma

Despite bioavailability issues, tea catechins have emerged as promising chemopreventive agents because of their efficacy in various animal models. We synthesized two catechin-derived compounds, 3-O-(3,4,5-trimethoxybenzoyl)-(-)-catechin (TMCG) and 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin (TMECG), in an attempt to improve the stability and cellular absorption of tea polyphenols. The antiproliferative and pro-apoptotic activities of both compounds were analyzed with various cancer cell systems, and TMCG, which was easily synthesized in excellent yield, was more active than TMECG in both melanoma and non-melanoma cell lines. TMCG was also a better inhibitor of dihydrofolate reductase and was more efficiently oxidized by tyrosinase, potentially explaining the difference in activity between these epimers.