128300-09-4Relevant articles and documents
CYTOTOXIC AGENTS
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, (2022/02/09)
The present invention provides a compound of formula (I): (T-X4)p-B1-X3-A-X2-L-X1-AM or pharmaceutically acceptable salts, tautomers, stereoisomers or mixtures thereof; wherein AM is (AM1); (AM2); or (AM3); with the proviso that the compound of formula (I) contains at least one sigma hole group; and with the proviso that no more than one of A, B1 and T is a sigma hole group; and each sigma hole group is independently: (SH1); (SH2); (SH3); (SH4); (SH5); (SH6); (SH7); (SH8); (SH9); or (SH10).
Synthesis, biological evaluation, and live cell imaging of novel fluorescent duocarmycin analogs
Tietze, Lutz F.,Behrendt, Frank,Pestel, Galina F.,Schuberth, Ingrid,Mitkovski, Mi?o
, p. 2559 - 2570 (2013/01/16)
For a better understanding of the mode of action of duocarmycin and its analogs, the novel fluorescent duocarmycin derivatives 13-15 and 17b-19b were synthesized, and their bioactivity as well as their cellular uptake investigated using confocal laser sca
Synthesis of N-(tert-Butyloxycarbonyl)-CBI, CBI, CBI-CDPI1, and CBI-CDPI2: Enhanced Functional Analogues of CC-1065 Incorporating the 1,2,9,9a-Tetrahydrocyclopropabenzindol-4-one (CBI) Left-Hand Subunit
Boger, Dale L.,Ishizaki, Takayoshi,Kitos, Paul A.,Suntornwat, Oranart
, p. 5823 - 5832 (2007/10/02)
Full details of the synthesis of N-(tert-butyloxycarbonyl)-1,2,9,9a-tetrahydrocyclopropabenzindol-4-one constituting a more stable functional analogue of the CC-1065 left-hand subunit are described.The resolution of an immediate CBI