128301-65-5

Basic information

• Product Name: (+)-(2S,3S)-3-{{(1S)-1-[(Benzyloxy)carbonyl]-2-(4-hydroxyphenyl)ethyl}carbamoyl}-oxiran-2-carbonsaeure-ethylester
• Synonyms: (+)-(2S,3S)-3-{{(1S)-1-[(Benzyloxy)carbonyl]-2-(4-hydroxyphenyl)ethyl}carbamoyl}-oxiran-2-carbonsaeure-ethylester
• CAS NO: 128301-65-5
• Molecular Weight: 413.427
• Mol File: 128301-65-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (+)-(2S,3S)-3-{{(1S)-1-[(Benzyloxy)carbonyl]-2-(4-hydroxyphenyl)ethyl}carbamoyl}-oxiran-2-carbonsaeure-ethylester(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-(2S,3S)-3-{{(1S)-1-[(Benzyloxy)carbonyl]-2-(4-hydroxyphenyl)ethyl}carbamoyl}-oxiran-2-carbonsaeure-ethylester(128301-65-5)
• EPA Substance Registry System: (+)-(2S,3S)-3-{{(1S)-1-[(Benzyloxy)carbonyl]-2-(4-hydroxyphenyl)ethyl}carbamoyl}-oxiran-2-carbonsaeure-ethylester(128301-65-5)

Safety Data

• Hazardous Substances Data: 128301-65-5(Hazardous Substances Data)

Upstream product

• 53587-11-4 L-tyrosine benzyl ester p-toluenesulfonate 
• 63734-73-6 ethyl (2S,3S)-2,3-epoxysuccinate 
• 3291-46-1 (2S,3S)-diethyl oxirane-2,3-dicarboxylate 
• 42406-77-9 L-tyrosine benzyl ester 

Downstream Products

• 245660-13-3 (+)-(2S,3S)-3-{[(1S)-1-Carboxy-2-(4-hydroxyphenyl)ethyl]carbamoyl}oxiran-2-carbonsaeure-ethylester 

Relevant articles and documents

Configuration and enantioselective synthesis of the fungal metabolite WF14861

A short enantioselective synthesis of the cathepsine inhibitor WF14861 (1) from the funghi Colletotrichum sp. as well as of its diasteroisomer 21 is presented. Comparison of the NMR data of the final products and, in particular, of the [α]D values of the intermediates allowed the confirmation of the formerly proposed structure 1. In addition, the so far unknown absolute configuration of all three stereogenic centres of WF14861 could be established by this synthesis.