1283155-61-2

Basic information

• Product Name: (R)-4,4,4-trifluoro-1-(4-fluorophenyl)-3-hydroxybutan-1-one
• CAS NO: 1283155-61-2
• Molecular Weight: 236.166
• Mol File: 1283155-61-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-4,4,4-trifluoro-1-(4-fluorophenyl)-3-hydroxybutan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4,4,4-trifluoro-1-(4-fluorophenyl)-3-hydroxybutan-1-one(1283155-61-2)
• EPA Substance Registry System: (R)-4,4,4-trifluoro-1-(4-fluorophenyl)-3-hydroxybutan-1-one(1283155-61-2)

Safety Data

• Hazardous Substances Data: 1283155-61-2(Hazardous Substances Data)

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 433-27-2 ethyl trifluoroacetaldehyde hemiacetal 
• 80646-00-0 3-(4-fluorophenyl)-3-oxopropanoic acid 
• 431-46-9 2,2,2-trifluoro-1-methoxy-ethanol 
• 824424-56-8 C₉H₇FO₃ 

Relevant articles and documents

C2-Symmetric Chiral Bisoxazolines as Hydrogen-Bond-Acceptor Catalysts in Enantioselective Aldol Reaction of β-Carbonyl Acids with Trifluoroacetaldehyde Hemiacetals

A simple C2-symmetric chiral bisoxazoline is demonstrated to use hydrogen bonding to catalyze an important family of aldol reactions of trifluoroacetaldehyde hemiacetals with various β-carbonyl acids. This reaction is highly enantioselective, delivering chiral nonracemic trifluoromethylated alcohols with excellent optical purity and good isolated yields. This concept of relaying chiral information via a chiral hydrogen-bond acceptor should be applicable to a vast number of organocatalytic processes.

Organocatalytic asymmetric direct aldol reactions of trifluoroacetaldehyde ethyl hemiacetal with aromatic methyl ketones

The organocatalytic asymmetric direct aldol reaction of trifluoroacetaldehyde ethyl hemiacetal with aromatic methyl ketones in the presence of a catalytic amount of (S)-5-(pyrrolidin-2-yl)-1H-tetrazole in dichloroethane at 40 °C proceeds smoothly to produ