1284258-81-6Relevant articles and documents
Induction of Apoptosis in Cancer Cells by Glutathione Transferase Inhibitor Mediated Hydrophobic Tagging Molecules
Li, Xiaona,Lü, Zirui,Wang, Cong,Li, Kebin,Xu, Fengrong,Xu, Ping,Niu, Yan
, p. 720 - 725 (2021)
The abnormally high expression of glutathione transferases is closely associated with cancer incidence and drug resistance. By introducing a hydrophobic moiety to the inhibitor structure, we organized a series of degraders of glutathione transferases and
Solution-phase parallel synthesis and screening of anti-tumor activities from fenbufen and ethacrynic acid libraries
Su, Yuan-Hsiao,Chiang, Li-Wu,Jeng, Kee-Ching,Huang, Ho-Lien,Chen, Jenn-Tzong,Lin, Wuu-Jyh,Huang, Chia-Wen,Yu, Chung-Shan
supporting information; experimental part, p. 1320 - 1324 (2011/04/16)
The derivatives with fenbufen and ethacrynic acid core compounds was synthesized through a facial preparation of 1-amino-4-azidobutane. The subsequent coupling with 102 members of carboxylic acids afforded amide products. The in situ screening using colorimetric assay with 3-(4.5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide showed that fenbufen but not ethacrynic acid butyl amide members displayed the cytotoxicities to tumor cells substantially, including two human cell lines (MCF7 and A549) and two murine cell lines (C26 and TRAMP-C1). Three fenbufen analogs were found to have a good anti-tumor activity comparable to cisplatin.