128535-90-0

Basic information

• Product Name: Benzenemethanol, a-(aminomethyl)-4-chloro-, (R)-
• Synonyms: (R)-2-Amino-1-(4-chloro-phenyl)-ethanol;(R)-2-(4-chloro-phenyl)-2-hydroxy-ethylamine
• CAS NO: 128535-90-0
• Molecular Formula: C8H10ClNO
• Molecular Weight: 171.626
• Mol File: 128535-90-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 94-95 °C
• Boiling Point: 319.8±27.0 °C(Predicted)
• Density: 1.260±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzenemethanol, a-(aminomethyl)-4-chloro-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-(aminomethyl)-4-chloro-, (R)-(128535-90-0)
• EPA Substance Registry System: Benzenemethanol, a-(aminomethyl)-4-chloro-, (R)-(128535-90-0)

Safety Data

• Hazardous Substances Data: 128535-90-0(Hazardous Substances Data)

Upstream product

• 149285-96-1 N-[(R)-2-(4-Chloro-phenyl)-2-hydroxy-ethyl]-acetamide 
• 6660-08-8 N-(2-(4-chlorophenyl)-2-oxoethyl)acetamide 
• 149342-40-5 N-(4-chloro-β-hydroxy-phenethyl)-acetamide 
• 5467-71-0 4-chlorophenacylamine hydrochloride 
• 13312-83-9 (R)-(+)-4-chloromandelonitrile 
• 26086-60-2 2-azido-4'-chloroacetophenone 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 1073-67-2 4-vinylbenzyl chloride 

Downstream Products

• 875467-74-6 (R)-2-(4-chloro-phenyl)-2-hydroxy-ethylamine hydrochloride 
• 943910-34-7 (R)-5-(4-chlorophenyl)oxazolidin-2-one 

Relevant articles and documents

Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein

Chiral 1,2-amino alcohols are widely represented in biologically active compounds from neurotransmitters to antivirals. While many synthetic methods have been developed for accessing amino alcohols, the direct aminohydroxylation of alkenes to unprotected, enantioenriched amino alcohols remains a challenge. Using directed evolution, we have engineered a hemoprotein biocatalyst based on a thermostable cytochrome c that directly transforms alkenes to amino alcohols with high enantioselectivity (up to 2500 TTN and 90 % ee) under anaerobic conditions with O-pivaloylhydroxylamine as an aminating reagent. The reaction is proposed to proceed via a reactive iron-nitrogen species generated in the enzyme active site, enabling tuning of the catalyst's activity and selectivity by protein engineering.

Asymmetric reduction of α-keto aldoxime o -ethers

The catalytic asymmetric reduction of -keto aldoxime O-methyl, O-benzyl, and O-trityl ethers, derived from substituted acetophenones, with borane/oxazaborolidines, by transfer hydrogenation, and with yeast, was studied. The reduction with borane/oxazaborolidines produced the corresponding -hydroxy oxime ethers, -hydroxy hydroxylamine ethers, and -amino alcohols in 39-78% yields and up to 77% ee. The carbonyl group was selectively reduced by transfer hydrogenation with formic acid-triethylamine catalyzed by RhCl[(R,R)-TsDPEN](Ce, and also with yeast, producing -hydroxy oxime ethers, up to 75% ee and 93% ee, respectively. Georg Thieme Verlag Stuttgart New York.

Indole, indazole and indoline derivatives as CETP inhibitors

The present invention relates to compounds of formula (I): wherein —X—Y—, R1 to R11 and n are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are mediated by CETP inhibitors.